نتایج جستجو برای: slco1b1
تعداد نتایج: 546 فیلتر نتایج به سال:
Abstract Background Context: Methotrexate (MTX) is a cornerstone in the treatment of juvenile idiopathic arthritis (JIA). MTX commonly associated with nausea. Large inter-individual variation exists level MTX-induced nausea, possibly due to genetic factors. Purpose: To investigate whether nausea was single nucleotide polymorphisms (SNPs) genes encoding MTX-transporter proteins, metabolizing enz...
Objective(s):Organic anion transporter polypeptide 1B1 (OATP1B1) encoded by solute carrier organic transporter 1B1 (SLCO1B1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. Aim of this study was to investigate the frequencies of functionally significant SNPs (388A>G and 521T>C) and their haplotypes in 6 ethnic groups of ...
Department of Discovery DMPK AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (MI, PB); Department of Medicinal Chemistry AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (RJR); Department of Bioscience AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (RJ); Metabolism and Pharmacokinetics, Bristol-Myers Squibb, 5 Researc...
OBJECTIVES We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. METHODS ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209) were prospectively enrolled in parallel to start efavirenz based HAART. CD4+ cell counts were determined at baseline, 12,...
The organic anion-transporting polypeptides (OATPs, gene symbol SLCO) are a family of transporters that play important roles in the absorption, distribution, metabolism, and excretion of various drugs. Although substrate specificity of transporter proteins is under extensive study, the underlying mechanisms for substrate binding and/or recognition remain largely unknown. Transmembrane domain 6 ...
This study was conducted to evaluate the likelihood of daprodustat to act as a perpetrator in drug-drug interactions (DDI) with the CYP2C8 enzyme and OATP1B1 transporter using the probe substrates pioglitazone and rosuvastatin as potential victims, respectively. Additionally, this study assessed the effect of a weak CYP2C8 inhibitor, trimethoprim, as a perpetrator of a DDI with daprodustat. Thi...
Methotrexate is used as first-line treatment of moderate to severe psoriasis. Despite the marked variability in outcomes, no pharmacogenetic markers are currently for personalised management therapy. In this retrospective study, we investigated effects genetic predisposition on efficacy and toxicity low-dose methotrexate a cohort 137 patients with plaque We genotyped 16 polymorphisms genes enzy...
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