EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We report here that deletion of EphA2 in mouse led to markedly enhanced susceptib...

in a study of 310 patients with suspected dermatophytic lesions, 110 cases of dermatophytosis, were diagnosed by direct smear in 10% koh and culture by two methods, skin stripping with use of adhesive tape and scrapping with scalpel blade conventional technique). out of 65 positive cultures, in 33 cases, growth was obtained by methods (scraping and stripping), 23 by the conventional technique a...

Chronic exposure of the skin to ultraviolet B (UVB) radiation induces oxidative stress, which plays a crucial role in the induction of skin cancer. In this study, the effect of dietary feeding and topical application of brown algae polyphenols on UVB radiation-induced skin carcinogenesis in SKH-1 mice was investigated. SKH-1 hairless mice were randomly divided into 9 groups, including control, ...

Cutaneous T-cell lymphomas (CTCL) are rare non-Hodgkin of skin-tropic T cells. Advanced-stage CTCL frequently refractory to treatment and early relapses common. There is a clear unmet need for new treatments with long-term efficacy in CTCL. CCR8 chemokine receptor expressed by skin resident memory cells which suspected be the tumor origin mycosis fungoides. also strongly tumor-infiltrating Treg...

Carcinogen-induced skin tumorigenesis depends heavily on proinflammatory tumor-promoting processes. Here, we show that leukocytic Runx3 expression is central to the two-stage DMBA/TPA-induced skin tumorigenesis. Runx3-null mice were highly resistant to this process and concomitant ablation of Runx3 in dendritic and T cells fully recapitulated this resistance. Mechanistically, this resistance wa...

Case Description- In this clinical report, occurrence of a rare case of canine cutaneous inverted papilloma was discussed. A 4-year-old, intact, male German shepherd dog was presented with multiple skin lesions, located on the inguinal region near the root of penis, which have been progressively growing since two months ago. In close examination of the lesions multiple, firm, painful, and cup-s...

Non-melanoma skin cancers (NMSC) are the most common malignant tumors in white population and their incidence has been increasing worldwide. Molecular events regulating cell survival, apoptosis, growth arrest as well as cell differentiation, are important contributors to the overall kinetics of benign and malignant cell growth and play a role in their development, progression and regression. Fa...

A case report is presented describing a clear cell sarcoma of the foot (malignant melanoma of soft parts). Melanoma is most commonly associated with pigmented lesions and nodules of the skin. Clear cell sarcoma (CCS) is an anaplastic tumor consisting of cells derived from melanoblasts not forming melanin in the skin, but rather mitotic changes more consistent with malignant melanoma in subcutan...

Cutaneous metastasis of renal cell carcinoma (RCC) is very rare. The author herein report two cases of RCC with cutaneous metastasis. Case 1: is a 75-year-old man with right lumbago. Imaging modalities including CT and MRI revealed a right renal tumor. Nephrectomy was performed. Pathological diagnosis of the renal tumor was RCC of clear cell type (Fuhrman's grade II). He denied follow-up. Nine ...