The simultaneous application of ultrasound and the surfactant sodium lauryl sulfate (referred to as US/SLS) to skin enhances transdermal drug delivery (TDD) in a synergistic mechanical and chemical manner. Since full-thickness skin (FTS) and split-thickness skin (STS) differ in mechanical strength, US/SLS treatment may have different effects on their transdermal transport pathways. Therefore, w...

INTRODUCTION The management of sensitive skin, which affects over 60% of the general population, has been a long-standing challenge for both patients and clinicians. Because defective epidermal permeability barrier is one of the clinical features of sensitive skin, barrier-enhancing products could be an optimal regimen for sensitive skin. In the present study, we evaluated the efficacy and safe...

The simultaneous application of ultrasound and the surfactant sodium lauryl sulfate (referred to as US/SLS) to skin enhances transdermal drug delivery (TDD) in a synergistic mechanical and chemical manner. Since full-thickness skin (FTS) and split-thickness skin (STS) differ in mechanical strength, US/SLS treatment may have different effects on their transdermal transport pathways. Therefore, w...

That the percutaneous absorption of substances can be facilitated by increasing the temperature and relative humidity of the skin seems to be generally accepted but rarely confirmed or refuted experimentally. Occlusive dressings are now in widespread use to enhance penetration of substances and probably owe their effectiveness to an increase in both temperature and moisture. Several authors (5—...

This paper presents multi-layer testing and analysis techniques to obtain layer permeabilities and skin factors using flow rate and transient pressure data which was generated into ECLIPSE100 simulation software. For the purpose of this study, we considered commingled reservoir and is defined as the joint production from two or more layers from a single common wellbore. For simplicity the commi...

BACKGROUND Literature data indicate that terrestrial life stages of amphibians may be more sensitive to xenobiotics than birds or mammals. It is hypothesized that dermal exposure could potentially be a significant route of exposure for amphibians, as there is evidence that their skin is more permeable than the skin of other vertebrate species. Thus, higher amounts of xenobiotics might enter sys...

A review of field production data reveals that usually, it is very difficult to apply available decline models because of poor quality and often noisy character of initial data and also unrealistic assumptions of the models. This paper tries to introduce applicable procedures to correct initial data and reproduce missed data. Corrected data are analyzed and finally, the results for permeability...

Docetaxel and prostaglandin E1 (PGE1) increase transcapillary albumin extravasation and reduce interstitial fluid pressure in the skin. In this study the microdialysate concentration (Cm) of 125I-labeled human serum albumin (125I-HSA) and different-sized endogenous plasma proteins (EPP) was compared to evaluate changes in transcapillary extravasation of plasma proteins. 125I-HSA was also used t...

Abstract Literature solubilities have been used to obtain properties or descriptors of melatonin. These indicate the chemical nature melatonin: it is dipolar and has moderate hydrogen bond acidity basicity. The can be combined with equations that we previously constructed estimate water–solvent partition coefficients in a huge number organic solvents. In same way, range biological estimated. in...