Amyloidosis are a large group of conformational diseases characterized by abnormal protein folding and assembly which results in the accumulation of insoluble protein aggregates that may accumulate systemically or locally in certain organs or tissue. In local amyloidosis, amyloid deposits are restricted to a particular organ or tissue. Alzheimer's, Parkinson's disease, and amyotrophic lateral s...

The severe acute respiratory syndrome coronavirus two (SARS-CoV-2), which causes the 2019 disease (COVID-19), has infected patients worldwide. Physicians have increasingly identified cutaneous findings as a significant clinical manifestation of COVID-19. In this review, we describe presentation, onset, duration, associated symptoms, treatment, and outcome manifestations thus far reported to be ...

Haemorrhagic skin necrosis is a common manifestation of a number of different pathological processes that can evolve dramatically and carry a grave prognosis. The divergent patho-physiological basis of the condition and the many specialities involved in the initial and subsequent care of the patient means that not all patients are seen by wound care professionals. Yet such patients do present t...

threatening condition which is distributed worldwide. Kaposi sarcoma is the most common malignancy in AIDS patients, and cutaneous Kaposi sarcoma is frequently the initial manifestation of the disease (1). Kaposi sarcoma associated with human immunodeficiency virus (HIV) is usually widely distributed on the skin and may also be widely disseminated internally, frequently with pulmonary involveme...

An-80-year-old woman treated with allopurinol showed atypical target lesions with blister and erosions, which rapidly extended over the trunk and limb. She was diagnosed as Toxic Epidermal Necrolysis (TEN). Despite the treatment with pulsed corticosteroids and i.v. immunoglobulins, the skin lesions rapidly extended over the entire body. Strikingly, the progression of blistering with stopped by ...

Mycoplasma is a virulent organism that is known to primarily infect the respiratory tract; however, affection of the skin, nervous system, kidneys, heart and bloodstream has been observed in various forms, which include Stevens Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, encephalitis, renal failure, conduction system abnormalities and hemolytic anemia. Small vessel vascul...

Cryptococcosis is a fungal infection of opportunistic behavior that is unusual in immunocompetent patients. We report a rare case of disseminated cryptococcosis with cutaneous involvement in an immunocompetent individual. During hospitalization, Cryptococcus gattii was isolated from skin lesions, lung and spinal fluid. The diagnosis of disseminated cryptococcosis was confirmed and treatment was...

Secondary syphilis has been known since the late 19th century as the great imitator; however, some experts now regard cutaneous lymphoma as the great imitator of skin disease. Either disease, at times an equally fastidious diagnosis, has reported to mimic each other even. It is thus vital to consider these possibilities when presented with a patient demonstrating peculiar skin lesions. No other...

Background Mycoplasma pneumoniae is widely known as the etiological agent of “atypical pneumonia”, the most common clinical aspects of the infection being bronchiolitis and acute tracheobronchitis. It can also determine extrapulmonary manifestation such as ear, nose and throat infections, neurological, cardiac or dermatological manifestations. Dermatological involvement is second most common, a...

Leukoderma and hypopigmentation can be a manifestation of 2 main mechanisms by which melanin might disappear from the skin. One is a dysfunction of the melanocytes; the other is loss of the melanocytes themselves. Hypopigmentation disorders can be localized or generalized. They can be either congenital/hereditary or acquired. The pattern of involvement can be circumscribed, diffuse, linear, or ...