BACKGROUND Mycobacterium tuberculosis lipid antigens take part in pathogenicity of the bacterium but the response of monocytes/macrophages to these antigens in tuberculosis is not well known. OBJECTIVE The aim of current investigation was to study the M. tuberculosis lipid antigens in tuberculosis pathogenesis. METHODS In the present study M. tuberculosis lipid antigens were extracted. Mono...

previous studies demonstrated that cse induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of cse in human health and disease. the present study was carried out to further characterize and compare toxic effect of cse extract on isolated mitochondria obtained from either a directly contacting tissue (i...

Lipid formulations, while gaining increasing importance in parenteral and oral drug delivery, are also important in transdermal and topical drug delivery. Examples and mechanisms by which lipids enhance the transport of drugs transdermally (through the skin) and topically (into the skin) will be discussed. Lipid formulations can form structures such as micelles, reverse micelles, emulsions, mic...

Liposomal encapsulation is known to signifi cantly improve the therapeutic index of a drug. In the present investigation liposomal formulations were chosen to transport clindamycin, which is considered as the most effective topical antibiotic for acne, into the skin layers. Liposomes with clindamycin phosphate were prepared using lipid fi lm hydration method and the optimum ratio of the compone...

Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin t...