While most of those infected with hepatitis C virus (HCV) are asymptomatic or only develop liver manifestations, a significant percentage evolves with autoimmune and lymphoproliferative disorders, resulting in a clinical condition called HCV syndrome. This work involving case studies of six patients with hepatitis C and varied skin manifestation aimed to report skin lesions occurring with HCV i...

cell-mediated immunity (cmi) plays an important role in resistance against leishmaniasis. delayed-type hypersensitivity (dth) reaction measured by skin testing is a practical method of evaluation of cmi and is used as an aid to diagnosis and for epidemiological assessment of exposure to leishmanial infection. skin testing in leishmaniasis, generally known as montenegro or leishmanin test, requi...

BACKGROUND The aim of this study was to investigate the effects of Leishmania major infection on the induction of oxidative stress in skin and lung of female mice. METHODS BALB/c mice were randomly divided into the control and experimental groups. The experimental groups were subcutaneously infected with inoculums promastigotes of L. major. The animals were sacrificed at 20, 40, 60, 90 and 12...

BACKGROUND Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine. METHODS We randomly assigned adults undergoing clean-contaminated surg...

BACKGROUND Several new polyomaviruses have been discovered in the last decade, including Merkel cell polyomavirus (MCPyV). Little is known about the natural history of the more recently discovered polyomaviruses. We estimated the incidence, prevalence, and persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HP...

Primary infection with varicella-zoster virus (VZV) causes the characteristic syndrome of varicella, or chickenpox. Experiments in severe combined immunodeficiency mice with human skin grafts (SCIDhu mice) indicate that VZV infection of T cells can mediate transfer of infectious virus to skin. VZV-infected T cells reached epithelial sites of replication within 24 h after entering the circulatio...

In the preceding paper it was shown that large numbers of pathogenic staphylococci must be injected intradermally into normal rabbits to induce a local skin infection (1). The apparent low infectivity of staphylococci in normal rabbit skin is similar to that observed by Elek (2) in human beings. Elek, however, demonstrated an increase in infectivity in the skin of volunteers when the microorgan...

conclusions several adverse effects are associated to anti-hcv drugs, hence appropriate skin care management and follow-up are very important. a careful anamnesis before the initiation of triple therapy is necessary to identify previous dermatological diseases that could increase skin adverse effects incidence. case presentation we report a case of a patient who discontinued telaprevir because ...