Bisphenol A (BPA) in vitro skin permeation studies have shown inconsistent results, which could be due to experimental conditions. We studied the impact of parameters on BPA using flow-through diffusion cells with ex-vivo human (12 donors, 3–12 replicates). varied status (viable or frozen skin) and thickness (200, 400, 800 μm), concentrations (18, 250 mg/l) vehicle volumes (10, 100 1000 μl/cm2)...

INTRODUCTION Lymphedema is the chronic swelling of an extremity that occurs commonly after lymph node resection for cancer treatment. Recent studies have demonstrated that transfer of healthy tissues can be used as a means of bypassing damaged lymphatics and ameliorating lymphedema. The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue ...

Responses to bovine PPD's, measured by the increase in skin thickness, ranged between 0 and 2.2 mm in the cervical test, and between 0 and 1.7 mm in the caudal fold test. According to interpretation criteria, all animals proved to be tuberculin-negative. The interval between reactions achieved and the minimal positive value was less for the simple cervical than for the caudal and comparative ce...

7. Lee CY, Lee KY, Kim KH, Kim YH. Total excision of acquired periungual fibrokeratoma using bilateral proximal nail fold oblique incision for preserving nail matrix. Dermatol Surg. 2010;36:139--41. 8. Carlson RM, Lloyd KM, Campbell TE. Acquired periungual fibrokeratoma: a case report. Cutis. 2007;80: 137--40. 9. Epstein E, Maibach HI. Monsel’s solution: history, chemistry, and efficacy. Arch D...

introduction: skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using varskin2. materials and methods: in this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90sr/90y, 147pm, 32p beta emitter radioisotopes by using input parameters: activity of source, ...

BACKGROUND The effect of physical and chemical permeation enhancers on in vitro transdermal permeation of lidocaine was investigated in the horse.Therefore, the effect of six vehicles (phosphate-buffered saline (PBS), 50% ethanol, 50% propylene glycol, 50% isopropylalcohol, 50% isopropylalcohol/isopropylmyristate and 50% dimethylsulfoxide) was examined as well as the effect of microneedle pretr...

Introduction: Skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using VARSKIN2. Materials and Methods: In this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90Sr/90Y, 147Pm, 32P beta emitter radioisotopes by using input parameters: activity of source, ...

In the present study a new alcohol derivative of tetrahydrogeraniol (THG), an acyclic monoterpene, has been prepared by using Grignard reagent and methyl cyclopropyl ketone. Penetration enhancing effects of THG and the synthesized derivative 5,9-dimethyl-2-cyclopropyl-2-decanol (DICNOL) on the transdermal penetration of 5-fluorouracil (5-FU) and tramadol hydrochloride (tramadol HCl) across the ...

The investigation deals with the affection of permeation of mupirocin from the Bactroban® Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the perme...