Predicting response to biotherapeutics remains a significant challenge in bioengineering, especially since the diffusion process of high molecular weight molecules human tissue largely unknown. This study presents an innovative microfluidic system therapeutic formulations ex vivo skin explants. The FlowSkin® model is based on implantation custom-made porous catheter into biopsy embedded proprie...

Kallikrein-related peptidases (KLKs) play a central role in skin desquamation. They are tightly controlled by specific inhibitors, including the lymphoepithelial Kazal-type inhibitor (LEKTI) encoded by SPINK5 and LEKTI-2 encoded by SPINK9. Herein, we identify SPINK6 as a selective inhibitor of KLKs in the skin. Unlike LEKTI but similar to LEKTI-2, SPINK6 possesses only one typical Kazal domain....

Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae, which affects not only the peripheral nerves and skin but also various internal viscera through the hematogenous spread, especially in lepromatous cases. The micropathological changes in epidermis, nerves and skin appendages from lesioned skin reported by various authors but reports of involvement of apparently normal sit...

BACKGROUND It is difficult to achieve satisfactory results with the traditional treatment of large-area skin defects and deep burns. OBJECTIVE To test the treatment effect of an active dressing film made of a mixture of fibrin glue and bone marrow mesenchymal stem cells (BMSCs) for repairing burn wounds on the skin of rats. METHODS Two scald wounds were made on the back of each rat. A total...

Introduction: The process of wound healing is best represented by an uninfected surgical wound. It characterized the formation granulation tissue, with migration and proliferation fibroblasts, neoangiogenesis production extracellular matrix. Granulation tissue gradually replaced scar made up connective and, in most cases - ended three or four weeks. whole takes about six weeks a newly formed ha...

A dermoid cyst is a benign cutaneous developmental anomaly that arises from the entrapment of ectodermal elements along lines embryonic closure. These tumors are lined by stratified squamous epithelium with mature skin appendages found on their wall and lumens filled keratin, hair, teeth etc. They usually in nature. Mature ovarian cysts very common accounting for 25% all neoplasms. Uncomplicate...

This study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila. Lack of Dll function causes a change in the identity of ventral appendage cells (legs and antennae) that often results in the loss of the appendage. Ectopic Dll expression in the proximal region of ventral appendages induces nonautonomous duplication of legs...

Rugosities on dermal bones of the skull have often been used to support inferences regarding unpreserved cutaneous appendages in extinct animals (e.g., horns). Such associations often seem obvious when examined in extant osteological specimens, where the conformation of epidermal appendages remains intact, but inferences regarding the type and morphology of unpreserved cutaneous appendages are ...