Twelve new tirucallane triterpenoids, named cornusalterins A-L (1-12), and two known tirucallane triterpenoids, deoxyflindissone (13) and (-)-leucophyllone (14), were isolated from a MeOH extract of stems and stem bark of Cornus walteri. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D NMR analyses. Compounds 12 and 13, possessing a tetrahydrofur...

A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2 α,3 α,19 α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2 α,3 β,21 α-trihydroxy-urs-12-en-28-oic acid ( 2), and 3 β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (4-10). The structures of these ne...

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The rate of breast cancer is rapidly increasing and discovering medications with therapeutic effects play a significant role in women’s health. Drugs derived from marine sponges have recently received FDA approval for the treatment malignant tumors, including metastatic cancer. Spirastrella pachyspira (marine sponge) mainly obtained western coastal region India, its anticancer potential has not...

The systems of bases are constructed for the spaces of cusp forms Sk(Γ0(3), χ) (k≥6), Sk(Γ0(7), χ) (k≥3) and Sk(Γ0(11), χ) (k ≥ 3). Formulas are obtained for the number of representation of a positive integer by the sum of k binary quadratic forms of the kind x1 +x1x2 +x 2 2 (6 ≤ k ≤ 17), of the kind x 2 1 +x1x2 +2x 2 2 (3 ≤ k ≤ 11) and of the kind x1 + x1x2 + 3x 2 1 (3 ≤ k ≤ 7). Let Fk denote ...

Cooperative regulation of inosiol-1,4,5-trisphosphate receptors (IP(3)Rs) by Ca(2+) and IP(3) has been increasingly recognized, although its functional significance is not clear. The present experiments first confirmed that depolarization-induced Ca(2+) influx triggers an outward current in visual cortex pyramidal cells in normal medium, which was mediated by apamin-sensitive, small-conductance...

Phosphoinositide-3 kinase (PI-3 kinase) and its downstream signaling molecules PDK-1 and Akt were analyzed in SK-N-SH and SK-N-BE(2) human neuroblastoma cell lines. When cells were stimulated with insulin, PI-3 kinase was activated in both cell lines, whereas the translocation of PDK-1 to the membrane fraction and phosphorylated Akt were observed only in SK-N-SH cells. Analyses of the insulin-m...

In Neurospora crassa, pairing of homologous DNA segments is monitored during meiotic prophase I. Any genes not paired with a homolog, as well as any paired homologs of that gene, are silenced during the sexual phase by a mechanism known as meiotic silencing by unpaired DNA (MSUD). Two genes required for MSUD have been described previously: sad-1 (suppressor of ascus dominance), encoding an RNA-...

There are increasing numbers of developed nanocarriers for anticancer drug delivery in the aim to avoid side effects conventional chemotherapy. Filomicelles with folic acid (FA) as a targeting moiety novel approach that can potentially maximize therapeutic efficacy while minimizing effects. The this study was analyze influence composition PLA-based micelles functionalized on their encapsulation...