OBJECTIVE To investigate the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1alpha (the IL1A gene), IL-1beta (the IL1B gene), and tumor necrosis factor alpha (the TNFA gene). DESIGN Prospective case-control trial. SETTING Tertiary referral center. PATIENTS Eighty-two patients with NP and 106 healthy volunteers...

Objectives: The goal of this study was to determine the validity, reliability, and internal consistency of the Rhinosinusitis Disability Index (RSDI) for evaluating nasal and sinus diseases in Turkey. Patients and Methods: The study included 120 patients (77 males, 43 females; mean age 39±12 years; range 18 to 65 years) with diagnoses of allergic rhinitis, chronic rhinosinusitis, nasal polyposi...

OBJECTIVE To evaluate improvements in otologic symptoms after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS), and identify differences in symptoms, if any, between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyposis. STUDY DESIGN Prospective multi-center observational cohort study. SETTING Academic tertiary medical centers. SUBJECTS AND METHODS Ad...

Myoepithelioma is a rare benign neoplasm. Pure accounting for less than 1% of all salivary gland tumors. Only three cases of sinonasal myoepithelioma have been reported in the literature. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. The lesion is so rare that there are no specific indications/guidelines for its tr...

INTRODUCTION The sinonasal malignant tumors are rare, representing less than 3% of the cervicofacialneoplasma and 0.8% of all human cancers. Approximately 55% have their origin in the maxillary sinuses, 35% in the nasal cavity, 9% in the ethmoid sinuses and 1% in the frontal and sphenoid sinuses. The malignant sinonasal tumors affect less than 1 person out of 100,000 individuals per year in mos...

PURPOSE To determine whether the MR finding of cysts along the intracranial margin of sinonasal esthesioneuroblastomas can be considered to suggest this tumor. METHODS MR scans of 54 patients who had sinonasal lesions with intracranial extension were examined specifically for cysts along the intracranial margins of the lesions. RESULTS Only 3 of the 54 patients had these cysts, and all 3 of...

OBJECTIVES/HYPOTHESIS Nasal disease, including chronic rhinosinusitis and allergic rhinitis, is a significant source of morbidity. Nasal irrigation has been used as an adjunctive treatment of sinonasal disease. However, despite an abundance of anecdotal reports, there has been little statistical evidence to support its efficacy. The objective of this study was to determine the efficacy of the u...

BACKGROUND High-resolution microendoscopy (HRME) enables real-time imaging of epithelial tissue. The utility of this novel imaging modality for inverted papilloma has not been previously described. This study examines the ability of otolaryngologists to differentiate between images of inverted papilloma and normal sinonasal mucosa obtained with a HRME. METHODS Inverted papilloma and normal si...

OBJECTIVE To study the expression of important elements of the innate immune responses in human sinonasal tissue to elucidate its potential role in mucosal inflammation. DESIGN We studied human sinonasal tissue from patients with chronic rhinosinusitis and an immortalized epithelial cell line to detect the expression of innate immune effectors and the responses of these cells to stimulation w...

OBJECTIVES/HYPOTHESIS Endoscopic orbital decompression (EnOD) has proven to be safe and effective for the treatment of Graves' orbitopathy; however, complications do occur. Although the literature focuses on orbital complications, sinonasal complications including postobstructive sinusitis, hemorrhage, and cerebrospinal fluid (CSF) leak can also be challenging to manage. This study examines the...