Odor perception depends on the odorant-evoked changes on Mitral/Tufted cell firing pattern within the olfactory bulb (OB). The OB exhibits a significant "ongoing" or spontaneous activity in the absence of sensory stimulation. We characterized this ongoing activity by simultaneously recording several single neurons in the mitral cell layer (MCL) of anesthetized rats and determined the extent of ...

Colors defined by the two intermediate directions in color space, "orange-cyan" and "lime-magenta," elicit the same spatiotemporal average response from the two cardinal chromatic channels in the lateral geniculate nucleus (LGN). While we found LGN functional magnetic resonance imaging (fMRI) responses to these pairs of colors were statistically indistinguishable, primary visual cortex (V1) fMR...

We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowi...

The paper discusses proposals for recording multiple single-unit potentials from nerve fibres that become captured in an array of tube electrodes. Capturing may be through regeneration. of cut fibres or by placement of dissected filaments into grooves which are then covered. The factors contributing to signal-to-noise ratios obtainable with this type of electrode are discussed. The design, cons...

Yamamoto J, Wilson MA. Large-scale chronically implantable precision motorized microdrive array for freely behaving animals. J Neurophysiol 100: 2430–2440, 2008. First published July 30, 2008; doi:10.1152/jn.90687.2008. Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for smal...

A method is described for the production of an electrode capable of monitoring and modulating the input-output relationship of thalamic neurons. Tungsten-in-glass electrodes were manufactured with the ability to simultaneously record lateral geniculate nucleus action potentials and associated, retinally evoked S-potentials. The recording electrodes were mounted onto multibarreled micropipettes ...

Rod photoreceptors contribute to vision over an ∼ 6-log-unit range of light intensities. The wide dynamic range of rod vision is thought to depend upon light intensity-dependent switching between two parallel pathways linking rods to ganglion cells: a rod → rod bipolar (RB) cell pathway that operates at dim backgrounds and a rod → cone → cone bipolar cell pathway that operates at brighter backg...

Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integr...

We propose a methodology for joint feature learning and clustering of multichannel extracellular electrophysiological data, across multiple recording periods for action potential detection and classification (“spike sorting”). Our methodology improves over the previous state of the art principally in four ways. First, via sharing information across channels, we can better distinguish between si...