Flaviviruses encode a single methyltransferase domain that sequentially catalyzes two methylations of the viral RNA cap, GpppA-RNA-->m(7)GpppA-RNA-->m(7)GpppAm-RNA, by using S-adenosyl-l-methionine (SAM) as a methyl donor. Crystal structures of flavivirus methyltransferases exhibit distinct binding sites for SAM, GTP, and RNA molecules. Biochemical analysis of West Nile virus methyltransferase ...

A previous paper (2] showed how to generate a linear discriminant network (LDN) that computes likely faults for a noisy fault detection problem by using a modification of the perceptron learning algorithm called the pocket algorithm. Here we compare the performance of this connectionist model with performance of the optimal Bayesian decision rule for the example that was previously described. W...

Introduction: Although strides have been made to improve breast augmentation surgery, they have focused on the use of single implant devices, necessitating adjustments to the type of operation performed and implants used. And although some breast types obtain excellent results, many others are less than optimal. By developing a thin synthetic expanded polytetrafluoroethylene device, the Pocket ...

Aim: Simultaneous or single stage mastopexy with augmentation is challenging, unique and commonly performed by a plastic surgeon. In this procedure pocket for implant placement, marking for envelope reduction and type of implants used can affect the outcome of the procedure. Muscle splitting pocket for mastopexy is a plane described by the author for implant placement with a short term follow u...

The intrinsic ability of protein structures to exhibit the geometric and sequence properties required for ligand binding without evolutionary selection is shown by the coincidence of the properties of pockets in native, single domain proteins with those in computationally generated, compact homopolypeptide, artificial (ART) structures. The library of native pockets is covered by a remarkably sm...

background: prevention of slipping accidents requires provision of adequate friction through the use of suitable combinations of footwear and underfoot surfaces. shoe sole tread groove is one of the important factors on friction coefficient during walking. objective: to measure the effect of different shoe sole tread groove depths and different surfaces on the required quotient of friction (q),...