Endocannabinoids are pleiotropic lipid messengers that play pro-homeostatic role in cellular physiology by strongly influencing intracellular Ca2+ concentration through the activation of cannabinoid receptors. One of the best-known endocannabinoid '2-AG' is chemically unstable in aqueous solutions, thus its molecular rearrangement, resulting in the formation of 1-AG, may influence 2-AG-mediated...

2-Arachidonyl glycerol (2-AG) is an endogenous arachidonic acid derivative that binds cannabinoid receptors CB1 and CB2 and is hence termed an endocannabinoid. 2-AG also modulates a variety of immunological responses, including expression of the autocrine/paracrine T cell growth factor interleukin (IL)-2. The objective of the present studies was to determine the mechanism responsible for IL-2 s...

In the present work, we demonstrate a facile way to study the biosynthesis of silver nanoparticles (Ag-NPs) with strong bactericidal properties using an aqueous extract of Scrophularia striata Boiss. The bio-reduction of Ag+ ions resulted in FCC cubic structures of Ag-NPs with spherical shapes of about 16 nm. As a main aim of the present work, the antibacterial activity of the bio-synthesized A...

Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Correspondent author: Seyed Mohammad Ali Shariatzadeh, [email protected] Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause toxicity in the ovaries. The aim of this study is to see if Spirulina platensis (SP) can protect m...

in this article, we give several generalizations of the concept of annihilating ideal graph over a commutative ring with identity to modules. weobserve that over a commutative ring $r$, $bbb{ag}_*(_rm)$ isconnected and diam$bbb{ag}_*(_rm)leq 3$. moreover, if $bbb{ag}_*(_rm)$ contains a cycle, then $mbox{gr}bbb{ag}_*(_rm)leq 4$. also for an $r$-module $m$ with$bbb{a}_*(m)neq s(m)setminus {0}$, $...

Extensive utilization increases the exposure of humans to Ag nanoparticles (NPs) via the oral pathway. To comprehensively address the action of Ag NPs to the gastrointestinal systems in real situations, i.e., the long-term low-dose exposure, we evaluated and compared the toxicity of three Ag NPs (20-30 nm with different surface coatings) to the human intestine cell Caco-2 after 1-day and 21-day...

Aminoglutethimide (AG) has been the most widely used aromatase inhibitor in breast cancer patients to date. Commercially, AG (Orimeten) is available as a racemate (DL-AG). Previous studies suggested the stereoisomers of AG (D-AG and L-AG) to differ considerably in their affinities and potencies to inhibit different cytochrome P-450-dependent enzymes, with D-AG being the potent aromatase inhibit...