نتایج جستجو برای: sickle cell anemia
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BACKGROUND Intravascular hemolysis in sickle cell anemia could contribute to complications associated with nitric oxide deficiency, advancing age, and increased mortality. We have previously reported that intense hemolysis is associated with increased risk of vascular complications in a small cohort of adults with sickle cell disease. These observations have not been validated in other populati...
BACKGROUND We have previously demonstrated that therapy with orally administered L-glutamine improves nicotinamide adenosine dinucleotide (NAD) redox potential of sickle red blood cells (RBC). On further analysis of L-glutamine therapy for sickle cell anemia patients, the effect of L-glutamine on adhesion of sickle RBC to human umbilical vein endothelial cells (HUVEC) was examined. METHODS Th...
The problems confronting the patient with sickle cell anemia have become well known. Only recently, however, has it been accepted that sickle cell trait per se (sicklemia) is capable of producing clinical symptoms and pathological findings.7’ ‘#{176}‘ 11 The development of conditions favorable to sickling, such as factors producing anoxemia and stasis, may precipitate symptoms in the otherwise ...
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