Phagocytosis of IgG-coated particles via FcgammaR is accompanied by the generation of superoxide and inflammatory cytokines, which can cause collateral tissue damage in the absence of regulation. Molecular mechanisms regulating these phagocytosis-associated events are not known. SHIP is an inositol phosphatase that downregulates PI3K-mediated activation events. Here, we have examined the role o...

The paper presents the design of a hybrid controller used to control the movement of a ship in different operating modes, thereby improving the performance of basic maneuvers. This task requires integrating several operating modes, such as maneuvering the ship at low speeds, steering the ship at different speeds in the course or along the trajectory, and stopping the ship on the route. These mo...

[no abstract available]

The current paper presents a methodology to compute and represent the ship motions at interactive frame rates, when navigating on a virtual sea defined by a real wave spectrum. The Inverse Discrete Fast Fourier Transform algorithm is used to compute the sum of all ship motions components induced by the waves and get the final irregular ship motion. Currently, this is the most efficient method t...

In recent years a great deal of research efforts in ship hydromechanics have been devoted to practical navigation problems in moving larger ships safely into existing harbors and inland waterways. An area of particular concern is the prediction of ship squat in shallow or restricted waters at different speeds. Squat may cause grounding of the ship which result in severe damage to the ship, and ...

Collision simulation of river-sea ship is accomplished based on nonlinear finite element method. Firstly, we discuss the development of collision analysis methods including theoretical methods, empirical formula method, experimental techniques and numerical analysis methods, and introduce the Central Difference Method adopted in the collision simulation. Then, model of ship structure and rigid ...

Molecular mechanisms by which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phagocytosis in macrophages are unclear. We addressed the issue using bone marrow–derived macrophages from Fc Ror SHIP-deficient mice. Phagocytic activities of macrophages from Fc RII(b) / and SHIP / mice were enhanced to a similar extent, relative to those from wild type. Howev...

Ship grounding is one of the primary maritime navigation casualties and a result of an error made by the navigating officer, of a technical failure on vital ship equipment or of force majeure. In order to decrease the risk of grounding in such cases, this paper explores the ship movement during navigation when an extraordinary event occurs, such as steering system failure that affects the vesse...

Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is unclear. Here, we show that DEPDC1B, a protein that accumulates in G2, coordinates de-adhesion events and cell-cycle progression at mitosis. DEPDC1B functions...