OBJECTIVES The aim of this study was to assess the performance of dynamic contrast-enhanced computed tomography of the prostate in patients with biopsy-proven prostate cancer. MATERIAL AND METHODS A total of 46 male patients (median age, 65 years; range, 49-73 years) with biopsy-proven prostate cancer underwent an en bloc computed tomography perfusion (CTP) scan of the prostate before surgery...

Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic beta-cells. Here, we show that exocytosis of SGs and insertion of ICA512 in the plasma membrane promotes the Ca(2+)-dependent cleavage of ICA512 cytoplasmic domain by mu-calpain. This cleavage occurs at the plasma membrane and generates an I...

There is a wide consensus in the scientific community about the educational potential of Serious Games (SGs). However, most authors highlight that more extensive tests need to be performed in order to provide valid and reliable evidence for effectiveness of SGs as educational tools. An effective application of SGs for education and training demands appropriate metrics, analytics, tools, and tec...

An organism placed under stress prioritizes activities essential for immediate survival, postponing or abandoning less pressing concerns. This is true at the cellular level, too; stressed cells can modify their systems to cope with damage and even prioritize protein translation toward those genes that will help them overcome the crisis (1). Crucial to this effort are cytoplasmic stress granules...

The use of polymer reinforced with fillers has increased in recent years as their properties have improved. thermoplastic matrix chosen for this study was Polypropylene (PP) and reinforcement Spheri-glass-3000 (SGS). melt mixing method used to produce PP/SGS nanocomposites the aid twin-screw-extruder. Test samples manufactured by injection-molding-machine. mechanical thermal produced been inves...

Processing bodies (PBs) and stress granules (SGs) are two highly conserved cytoplasmic ribonucleoprotein foci that contain translationally repressed mRNAs together with proteins from the mRNA metabolism. Interestingly, they also share some common features with other granules, including the prokaryotic inclusion bodies. Although the function of PBs and SGs remains elusive, major advances have be...

Digital technologies have increased the pace of knowledge creation, sharing, and the way in which learning is being undertaken. This chapter considers how Serious Games (SGs) as a digital technology endeavours to support effective lifelong learning. Three fundamental characteristics of the SG ecosystem, namely, game mechanics, interoperability, and assessment, are considered here as strategic e...

Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now show that cells lacking both G3BP1 and G3BP2 cannot form SGs in response to eukaryotic initiation factor 2α phosphorylation or eIF4A inhibition, but are still SG-competent when challenged with severe heat or osmotic s...

tremendous outburst these last years. Video game companies have been producing fun, user-friendly SGs, but their educational value has yet to be proven. Meanwhile, cognition research scientist have been developing SGs in such a way as to guarantee an educational gain, but the fun and attractive characteristics featured often would not meet the public's expectations. The ideal SG must combine th...