The aim of the present study is to develop colon targeted drug delivery systems for metronidazole using sesbania gum as a carrier. Matrix, enteric coated and compression coated tablets of metronidazole containing various proportions of sesbania gum were prepared. All the formulations were evaluated for the hardness, drug content uniformity, and were subjected to in vitro drug release studies. M...

Abstract Purpose The classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it impossible reach desired using this alone. Therefore, a novel approach combination ball milling and technology was investigated improve for celecoxib. Methods First, celecoxib dispersed liquid vehicle (PEG 200), then ground mill 3 h. Other excipients, in...

Program Saemaul Undong yang pernah diterapkan di era Presiden Park Chung Hee 1963-1979, telah menjadi gerakan global Asia dan Afrika. Melalui Globalization Foundation (SGF) Korea Selatan, program beberapa desa Indonesia, salah satunya Desa Ponjong, Kabupaten Gunung Kidul Yogyakarta. Penerapannya dipadukan dengan Undang-Undang No. 6 tahun 2014. Akibatnya, peran BUMDes bergerak semakin optimal, p...

The [ornntlation of planning as heuristk: search with heuristics derived from problem representations ]nas turned out to be a fruitful approach for cla..,...ical planning. In this paper, we, pur.,,ue a sinnilar idea in Ihe context pLa.nning with incomplete inh)rmation. Planning with incomphit.e iTnforntalion can be formulatvd as a pmbh’nt of search in &.liqf space, where b(l&f stat~ can be ell ...

Curcumin is a natural compound present in Indian spice turmeric. It has diverse pharmacological action but low oral solubility and bioavailability continue to limit its use as a drug. With the aim of improving the bioavailability of Curcumin (CUR), we evaluated Curcumin-Pyrogallol (CUR-PYR) cocrystal and Curcumin-Artemisinin (CUR-ART) coamorphous solid. Both of these solid forms exhibited super...

The present investigation is concerned about the development of floating bioadhesive drug delivery system of venlafaxine hydrochloride which after oral administration exhibits a unique combination of floating and bioadhesion to prolong gastric residence time and increase drug bioavailability within the stomach. The floating bioadhesive tablets were prepared by the wet granulation method using d...

The aim of the present study was to formulate and investigate the calcium alginate- (CA-) Neusilin US2 nanocomposite microbeads containing preconcentrate of aceclofenac sodium (ACF-Na) liquid microemulsion (L-ME) for enhancement of oral bioavailability. The preconcentrate L-ME is prepared by using Labrafac PG, Labrasol, and Span 80 as oil, surfactant, and cosurfactant, respectively. The solid C...

The soybean Kunitz trypsin inhibitor (SKTI) is a 21.5 kDa allergenic protein that belongs to the family of all antiparallel beta-sheet proteins that are highly resistant to thermal and chemical denaturation. Spectroscopic and biochemical techniques such as circular dichroism (CD), ANS fluorescence and proteolysis were used to study its molecular structure under denaturing conditions such as aci...

The objective of this research was to design a new colon‐targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation de...

Synthetic waveform modeling of the anomalous receiver functions for two stations in the eastern San Gabriel Mountains, California, suggests that a flat-topped notch structure exists on the Moho. North of the San Andreas Fault (SAF), the Moho depth is 36–38 km and is 33–35 km south of the San Gabriel Fault (SGF), but in-between under the Mt. Baldy block, it is only ∼29 km. The inferred notch str...