نتایج جستجو برای: serum leptin

تعداد نتایج: 319768  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Giuseppe Matarese Pietro Biagio Carrieri Antonio La Cava Francesco Perna Veronica Sanna Veronica De Rosa Daniela Aufiero Silvia Fontana Serafino Zappacosta

We analyzed the serum and cerebrospinal fluid (CSF) leptin secretion and the interaction between serum leptin and CD4(+)CD25+ regulatory T cells (T(Regs)) in naive-to-therapy relapsing-remitting multiple sclerosis (RRMS) patients. Leptin production was significantly increased in both serum and CSF of RRMS patients and correlated with IFN-gamma secretion in the CSF. T cell lines against human my...

Journal: :Journal of applied physiology 2007
Richard A Johnston Todd A Theman Raya D Terry Erin S Williams Stephanie A Shore

Leptin is a satiety hormone that also has proinflammatory effects, including augmentation of ozone-induced pulmonary inflammation. The purpose of this study was to determine whether reductions in endogenous levels of leptin can attenuate pulmonary responses to ozone. To reduce serum leptin, we fasted mice overnight before ozone exposure. Fasting caused a marked reduction in serum leptin to appr...

Journal: :iranian journal of basic medical sciences 0
zahra mirfeizi rheumatic diseases research center, school of medicine, mashhad university of medical sciences, mashhad, iran zohreh noubakht rheumatic diseases research center, school of medicine, mashhad university of medical sciences, mashhad, iran ali etemad rezaie medical research assistant, university of toronto, toronto, on, ca mohammad hassan jokar rheumatic diseases research center, school of medicine, mashhad university of medical sciences, mashhad, iran zhaleh shariati sarabi rheumatic diseases research center, school of medicine, mashhad university of medical sciences, mashhad, iran

objective (s):rheumatoid arthritis (ra) is a chronic systemic inflammatory disorder, primarily targeting the synovium and articular cartilage that leads to joint damage. recent reports have suggested the role of adipocytokines in mediating joint damage; however it still is a matter of debate. the purpose of this study was to evaluate the association between serum values of adiopocytokines (lept...

صادقی, کریم, ضرغامی, نصرت الله , مستفیدی, هاله, مصطفی قره باغی, منیژه,

Background & Aims: Retinopathy of prematurity (ROP) is one of the most causes of retinal detachment and blindness. Although many studies have been conducted on the pathophysiology of ROP, the exact mechanism is yet under investigation. This study aimed at evaluating the role of serum vascular endothelial growth factor (VEGF), insulin like growth factor-I (IGF-I), and its binding protein (IGFBP-...

Journal: :Endocrinology 1999
Oreste Gualillo Francisca Lago Maria Garci A Carmen Mene Ndez Rosa Sen Ari S Felipe F Casanueva Carlos Die Guez

Leptin, the obese (Ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food intake and body weight. Leptin signals nutritional status to several other physiological systems and modulates their function. As PRL is involved in energy and lipid metabolism, this study was undertaken to investigate the role of PRL on in vivo regulation of leptin serum conce...

Journal: :The Journal of clinical endocrinology and metabolism 1997
C Schubring W Kiess P Englaro W Rascher J Dötsch S Hanitsch A Attanasio W F Blum

The mechanisms by which maternal and fetal weight are regulated during pregnancy are poorly understood. The ob protein, termed leptin, is produced by adipocytes. It is involved in the regulation of body weight by suppressing appetite and stimulating energy expenditure both in humans and rodents. In this study we examined whether leptin concentrations in the mother and the newborn correlate with...

2013
Ghorban Mohammadzadeh Nosratollah Zarghami

BACKGROUND Leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus. OBJECTIVES This study aimed to evaluate variations in serum leptin levels in non-obese subjects with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS We studied forty-one patients with type 2 diabetes. Fasting lipid profile, Hemoglobin A1c (HbA...

2013
Atqah Abdul Wahab Muna M. Maarafiya Ashraf Soliman Noura B. M. Younes Prem Chandra

There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese a...

Journal: :The Journal of clinical investigation 1997
M Wabitsch W F Blum R Muche M Braun F Hube W Rascher E Heinze W Teller H Hauner

Recent studies demonstrated significantly higher serum leptin concentrations in females as compared with males, even after correction for differences in body fat mass. The aim of our study was to measure serum leptin concentrations in a large group of obese children and adolescents to determine the possible role of sex steroid hormones on both leptin serum concentrations and production in human...

2017
Sungin Lee Oh-Kyeong Kweon Wan Hee Kim

Leptin and its receptor play several physiological roles in the canine gallbladder, and the dysregulation of leptin might play a role in the pathogenesis of gallbladder diseases such as gallbladder mucocele. Previous studies revealed a positive association between hyperlipidemia and gallstones in humans. However, the latter is still unclear in dogs with cholelithiasis. In this study, we examine...

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