OBJECTIVE Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of iron deficiency anemia. The objective of this study was to evaluate the oxidative status and to determine whether there is any relationship between oxidative status and the severity of anemia in patients with iron deficienc...

Beta-thalassemia is an inherited anemia in which synthesis of the hemoglobin beta-chain is decreased. Clinical features of beta-thalassemia include variably severe anemia and iron overload due to increased intestinal iron absorption, which may result in damage to vital organs. The hepatic peptide; hepcidin is a key regulator of iron metabolism in mammals. The present study aimed to determine th...

BACKGROUND AND OBJECTIVES To assess the distribution of serum ferritin, serum soluble transferrin receptor and body iron among girls and women by age and anaemia. METHODS AND STUDY DESIGN Serum ferritin, serum soluble transferrin receptor and high sensitive C-reactive protein of 1625 and 1372 women in general and anaemic were measured in the National Health and Nutrition Survey commenced in 2...

OBJECTIVE To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. METHODS This prospective, cross-sectional, case controlled study was carried out between January and June 2013, and included 98 iron deficiency and/or iron deficiency anemia, and 102 h...

Twenty-eight children with beta-thalassaemia major aged between 11 and 48 months were given intensive transfusions. Serum iron, transferrin saturation, serum ferritin, non-transferrin iron, and subcutaneous desferrioxamine-induced urinary iron excretion were measured. The results showed that even children with a limited number of transfusions had severe iron overload as indicated, in particular...

Masawe, A. E. J., and Rwabwogo-Atenyi, J. (1973). Archives of Disease in Childhood, 48, 927. Serum protein and transferrin determinations to distinguish kwashiorkor from iron deficiency anaemia. Serum proteins and serum transferrin levels were studied in 38 African children of whom 10 were normal controls, 18 had severe iron deficiency anaemia, and 10 had kwashiorkor. The results showed that th...

Original Article Background & objectives: To assess the nutritional iron status and anemia prevalence in rural children of Warangal district, A.P. INDIA. Methods: We have studied serum iron, total iron-binding capacity (TIBC) relation ship in 50 rural children in the age group of 8-12 years. Results: As expected there was a highly significant increased levels of serum iron and a lower TIBC. The...

A simple method is described for the automated determination of serum iron and tota iron-binding capacity, which eliminates the need to render apparatus or reagents iron-free. The method is faster than normal procedures and its accuracy is comparable with other accepted methods for the determination of serum iron.

Previous reports have shown that endotoxin decreases serum iron in experimental animals. In this study fever was produced in nine female and nine male normal subjects in order to define the temporal and quantitative changes in serum iron and ferritin concentrations. Six volunteers were randomly given bacterial endotoxin (5 ng/kg) or saline intravenously and received the alternative compound a w...

BACKGROUND Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD an...