IMPORTANCE Serotonin reuptake inhibitors (SRIs) are efficacious treatments for premenstrual dysphoric disorder (PMDD) when given daily or for half of the menstrual cycle during the luteal phase. Preliminary studies suggest that SRI treatment can be shortened to the interval from symptom onset through the beginning of menses. OBJECTIVE To determine the efficacy of symptom-onset dosing with the...

Background Different studies have been conducted to find the best adjuvant therapies for depression management. There are controversies over the effects of aspirin as an adjuvant therapy for depression. Objective To determine the effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder. Methods This randomized clinical trial was...

Cytochrome P450 (P450) 2B6 metabolizes a number of clinically relevant drugs and is one of the most highly polymorphic human P450 enzymes, with the Lys(262)-->Arg substitution being especially common in several genetic variants. Therefore, K262R (2B6*4) was created in the CYP2B6dH background (N-terminal-modified and C-terminal His-tagged) and expressed in Escherichia coli. The recombinant CYP2B...

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for patients with comorbid diabetes and depression. Clinical case studies in diabetic patients, however, suggest that SSRI therapy may exacerbate hypoglycemia. We hypothesized that SSRIs might increase the risk of hypoglycemia by impairing hormonal counterregulatory responses (CRR). We evaluated the effect of the SSRI sertral...

Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to interact with several receptors and ion channels. However, the molecular mechanisms that underlie the effects of antidepressants have not yet been...

serotonin specific reuptake inhibitors (ssri) may induce antinociception however, the mechanism of this effect is not clear. ssrls increase 5-ht levels in neuronal synapses and facilitate serotonergic activity. in this study, therefore, the activity of para-chlorophenylalanine (pcpa), which reduces 5-ht release, and 5- hydroxy tryptophan (5-htp), a precursor of 5-ht, were examined on the antino...

Sertraline is known to undergo changes in pharmacokinetics during pregnancy. CYP 2C19 has been implicated the interindividual variation clinical effect associated with sertraline activity. However, knowledge of suitable dose titrations pregnancy and within phenotypes lacking. A pharmacokinetic modeling virtual trials approach was implemented to: (i) assess gestational trough plasma concentratio...

Annona muricata L. (Annonaceae) is widely used in the Amazon and Carribean natural medicine as an antiparasitic, insecticidal, sedative astringent for diarrhea among others. In Nigeria however, under-utilized species of plants. This study investigated antidepressant ambulatory effect A. muricata, using open field test forced swim tests on Sprague-Dawley rats administered ethanol stem-bark extra...

OBJECTIVES 1) To review SSRI prescribing patterns for children and adolescents in our hospital and provincial prescription database and 2) To evaluate whether prescribing practices are consistent with expectations, based on published evidence and practice recommendations. METHODS A PubMed online search was conducted to obtain all randomized controlled trials assessing efficacy of SSRI use in ...

Young children with fragile X syndrome (FXS) often experience anxiety, irritability, and hyperactivity related to sensory hyperarousal. However, there are no medication recommendations with documented efficacy for children under 5 years old of age with FXS. We examined data through a chart review for 45 children with FXS, 12-50 months old, using the Mullen Scales of Early Learning (MSEL) for ba...