Cattle ticks, Rhipicephalus (Boophilus) microplus, have a serious impact on livestock worldwide. For tick control, host vaccination is more sustainable than chemical. Salivary serpin (serine protease inhibitor) from R. microplus (RmS-3) potential anti-tick vaccine candidate antigen. Like other serpins, RmS-3 has suicide inhibition mechanism, where the reactive centre loop (RCL) cleaved and then...

Alpha-1 antitrypsin (AT) is a member of the serine proteinase inhibitor (SERPIN) superfamily. It is an acute phase protein produced constitutively, primarily by hepatocytes, and is secreted in to the plasma from where it diffuses into the lung. AT is the most abundant proteinase inhibitor within the lung whose main physiological role is to regulate neutrophil elastase (NE) liberated from activa...