نتایج جستجو برای: serms
تعداد نتایج: 327 فیلتر نتایج به سال:
selective estrogen receptor modulators (serms) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. the purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placeb...
Background Tamoxifen is used as a selective estrogen receptor modifier (SERM) to treat hormone receptor-positive breast cancer. Raloxifene, another SERM, has been for the treatment of osteoporosis in post-menopausal women. The aim this cross-sectional study was examine whether history tamoxifen or raloxifene use associated with cognitive performance, odds mild impairment (MCI), structural neuro...
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabolites. Nontumorigenic MCF-10A human breast epithelial cells are classified as ER(-) and undergo estrogen-induced malignant transformation. Selective...
BACKGROUND Solid-pseudopapillary neoplasms of the pancreas (SPNs) are uncommon tumours usually frequent in young women. Although the pathogenesis of SPNs is uncertain a potential influence of the sex hormone milieu on the biology of these tumours has been suggested. The controversial expression of oestrogen receptors (ERs) in SPNs, provide a rationale for studying the effects of oestrogenic mol...
Osteoporosis is a skeletal metabolic disease characterized by a compromised bone fragility, leading to an increased risk of developing spontaneous and traumatic fractures. Osteoporosis is considered a multifactorial disease and fractures are the results of several different risk factors both extra- and intraskeletal. Thus bone fragility can be the end point of several different causes: a) failu...
Osteoporosis is defined as a decrease of bone mass and strength, well an increase in fracture risk. It conventionally treated with antiresorptive drugs, such bisphosphonates (BPs) selective estrogen receptor modulators (SERMs). Although both drug types successfully the risk fractures, their effect on strength different. For instance, BP treatment causes mass, stiffness whole bones, whereas SERM...
Abstract Background In spite of the significant escalation in depth our conception and regulation breast cancer over past decades, malady is still a serious community health challenge globally poses substantial tasks. Selective estrogen modulators (SERMs) such as Tamoxifen are approved for therapy this illness but developed drug resistance unwanted side effects endometrial caused by long-term c...
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