STUDY OBJECTIVES C-reactive protein (CRP) is an acute-phase protein, the blood levels of which increase rapidly in response to infection, trauma, ischemia, burns, and other inflammatory conditions. Although used frequently in the ICU as a sepsis marker, the relation of CRP levels to organ damage is not well known. This study assessed the association between early serum CRP concentrations and th...

OBJECTIVE The objective of this study was to determine the epidemiology and outcomes of intra-abdominal hypertension in a heterogeneous intensive care unit population. DESIGN This was a prospective cohort study. SETTING This study was conducted at a medical-surgical intensive care unit in a university hospital. PATIENTS Study patients included all those consecutively admitted during 9 mon...

OBJECTIVE To determine early predictors of outcomes of adult patients with severe acute respiratory failure. METHOD 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SOFA) score, Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) score, PaO...

OBJECTIVES We hypothesize that three inflammation pathobiology phenotypes are associated with increased inflammation, proclivity to develop features of macrophage activation syndrome, and multiple organ failure-related death in pediatric severe sepsis. DESIGN Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple orga...

Acute severe pancreatitis caused high mortality, and several scoring systems for predicting mortality are available. We evaluated the effectiveness of serial measurement of several scoring systems in patients with acute severe pancreatitis.We retrospectively obtained serial measurements of Ranson, Acute Physiology and Chronic Health Assessment (APACHE) II, and Sequential Organ Failure Assessmen...

Sepsis remains a major global healthcare problem, indicate as most frequently cause of morbidity and mortality worldwide. The last consensus sepsis in 2016 defined life threatening organ dysfunction caused by dysregulated host response to infection. Dysfunction organs can be represented Sequential [Sepsis-Related] Organ Failure Assessment (SOFA) score. Score2 points or more consequent the Nowad...

OBJECTIVE In certain physiologic systems, disease is associated with a loss of complexity in system's output. We test the hypothesis that, in critically ill patients, there is an inverse relation between the complexity of the temperature curve and the clinical status. We also consider whether complexity analysis of the temperature curve may have prognostic value. DESIGN Prospective, observati...

OBJECTIVE To investigate whether common infection foci (pulmonary, intra-abdominal and primary bacteraemia) are associated with variations in mortality risk in patients with sepsis. DESIGN Prospective, observational cohort study. SETTING Three surgical intensive care units (ICUs) at a university medical centre. PARTICIPANTS A total of 327 adult Caucasian patients with sepsis originating f...