Endothelium dysfunction is one of the hallmarks of sepsis. Looney and Mattay, in the previous issue of Critical Care, highlight the role of activated protein C (APC) as a protective endothelial drug in septic situations. Nevertheless, the results of in vivo studies are less explicit and it remains uncertain whether these properties are relevant in human septic shock. Before considering recombin...

Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (72 μg/kg, ...

Background & Objective: Bacterial, contamination of blood components are a significant risk for transfusion reactions. Inherently, platelet concentrates (PCs) are vulnerable to bacterial contamination, due to the storage condition of processed PCs at room temperature, which provide very suitable conditions for the proliferation of microorganisms....

Background: Arthroscopic reconstruction of ACL is an effective method to restore knee stability after ACL rupture.Postoperative septic arthritis (SA) is very uncommon while the incidence of serious complications range between0.14% and 1.8%. Some of the devastating consequences of septic arthritis can encompass hyaline cartilage damage,arthrofibrosis, and in rare cases amputation. The purpose of...

The review article, “Mitochondrial Mechanisms in Septic Cardiomyopathy” by Cimolai and colleagues, examines the role that mitochondria may play in the pathogenesis of cardiac dysfunction, a well-described, life-threatening complication in patients with severe sepsis and septic shock. Despite current therapies that mostly aim to reduce systemic infection and inflammation, sepsis remains the bigg...

Mosquito breeding occurred in. both types of septic tanks, wz'th Type A septic tanks shounng heatner breeding, Seventy-two (55.4 percent) of the 130 Type A septic tanks inspected had Aedes albopictus breeding. Besides being a nuisance, mosquito breeding is a potential threat to public health, as Ae. albopictus is a vector of dengue fever. Prolific breeding by Ae. albopictus was encountered in. ...

Results Septic patients (n = 442) had higher mortality rate than non-septic (n = 777) in the ICU (41.6 vs. 13.6%, p < 0.0001), and after two years (74.8 vs. 42.3%, p < 0.0001) Figure. The QOL of septic patients was lower than the non-septic at ICU admission and after two years. (1) Karnofsky pre-ICU 84 ± 11 vs. 88 ± 16 (p = 0.02), after 2 years: 76 ± 19 vs. 82 ± 17 (p = 0,007); ADL pré-ICU 26 ±...

Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these ...

A 6 yr old female spayed Labrador retriever was examined for severe pain and a nonweight-bearing right forelimb lameness due to swelling and wounds with direct communication into the elbow joint. The medical management of β hemolytic Streptococcus septic arthritis with needle lavage of the joint, systemic and local antibiotic therapy, and analgesic therapy is described. This case provides infor...