Sepsis-related mortality and morbidity are the leading issues that neonatal intensive care units struggle with worldwide. We report a preterm infant with septic shock and intractable metabolic acidosis whose postmortem microbiologic examination revealed Chryseobacterium meningosepticum meningitis. We would like to alert clinicians about this uncommon sepsis agent, and to call into question the ...

Identifying single nucleotide polymorphisms (SNPs) in the genes involved in sepsis may help to clarify the pathophysiology of neonatal sepsis. The aim of this study was to evaluate the relationships between sepsis in pre-term neonates and genes potentially involved in the response to invasion by infectious agents. The study involved 101 pre-term neonates born between June 2008 and May 2012 with...

BACKGROUND Chronic kidney disease (CKD) and systemic inflammation are risk factors for sepsis. While often viewed as a marker of chronic kidney disease, Cystatin C (Cyst-C) may also reflect systemic inflammation. We sought to determine the association between elevated baseline Cyst-C and long-term rates of community-acquired sepsis, and to determine if this relationship is influenced by traditi...

Infectious disease is common in stem cell transplant recipients, especially in the patients of primary immunodeficiency disease (PID). However, there’s little report about sepsis and meningitis caused by enterococcus faecium (EF). Meningitis and sepsis caused by EF is uncommon in stem cell transplant recipients. We report a case of EF meningitis and sepsis which occurred in a 2-year-old boy wit...

Abstract Background COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia fibrosis. The molecular response pathway such pathologies our recent observations on anti-hypoxic anti-inflammatory effects of whole aqueous extract Adhatoda Vasica (AV) prompted us to explore its relevant preclinical mouse models...

BACKGROUND We aimed to determine whether sepsis is associated with neurocognitive outcomes 4.5 years after congenital heart disease surgery in early infancy. METHODS AND RESULTS A secondary analysis from a prospective inception cohort included all children having congenital heart disease surgery done at ≤6 weeks of age with cardiopulmonary bypass at the Western Canadian referral center from 1...

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on an understanding of the basic mechanisms of the disease. The pathophysiology of severe sepsis involves a highly complex, integrated response that includes the activation of a number of cell types, inflammat...

Sepsis is an inflammatory response triggered by infection, with risk of in-hospital mortality fueled by disease progression. Early recognition and intervention by multidisciplinary sepsis programs may reverse the inflammatory response among at-risk patient populations, potentially improving outcomes. This retrospective study of a sepsis program enabled by a 2-stage sepsis Clinical Decision Supp...


 Near-infrared spectroscopy (NIRS) is a noninvasive method for measuring tissue oxygenation. The allows monitoring perfusion in shock by revealing hemoglobin oxygen saturation (StO2). current study aims to compare oxygenation levels with hemodynamical and lactate patients severe shock. Study encompasses 19 treated intensive care unit (ICU) at Alexandrovska University Hospital. Ten of the ...