BACKGROUND There is a need for a clear and actionable definition of maternal sepsis, in order to better assess the burden of this condition, trigger timely and effective treatment and allow comparisons across facilities and countries. The objective of this study was to review maternal sepsis definitions and identification criteria and to report on the results of an expert consultation to develo...

background: the purpose of this study was to determine the relationship between early onset sepsis and increased levels of c-reactive protein (crp) and interleukin-6 (il-6) in cord plasma.   methods: a prospective study was conducted in 141 premature infants delivered with gestational ages of 26-35 weeks. il-6 and cpr were measured by enzyme-linked immunoassay in the cord plasma of the neonates...

Background: With the increase in the number of premature neonates, there are concerns about the complications of this group. One of the common complications of preterm neonates is fungal sepsis. Therefore, this study was conducted to evaluate the efficacy of intravenous fluconazole on fungal sepsis and other complications related to premature newborns under 1200 g in a neonatal intensive care u...

Abstract Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, raise the mortality rate with an incidence up to 71%. Pathological neuroinflammation after sepsis leads acute brain dysfunction, survivors may remain long-term cognitive impairment. At present, evaluation SAE severity and prognosis mainly depends on clinical manifestations imaging features, but lack effectivenes...

BACKGROUND AND OBJECTIVE Early identification and treatment of severe sepsis and septic shock improves outcomes. We sought to identify and evaluate children with possible sepsis on a pediatric medical/surgical unit through successful implementation of a sepsis identification pathway. METHODS The sepsis identification pathway, a vital sign screen and subsequent physician evaluation, was implem...

BACKGROUND Thrombocytopenia is one of the most common laboratory abnormalities encountered in patients with severe sepsis. It has been reported that thrombocytopenia is linked to mortality in patients with severe sepsis. However, the mechanism of thrombocytopenia in sepsis is unknown. We hypothesized that inflammatory cytokines and microRNAs (miRNAs) are not only involved in the pathogenesis of...

Sepsis, the most common cause of admission to an intensive care unit (ICU), has had an increased incidence and prevalence over the last years with a simultaneous decrease in its short-term mortality. Sepsis survivors are more frequently discharged from hospital and often experience long-term outcomes such as late mortality, immune dysfunction, secondary infections, impaired quality of life, and...

Sepsis-induced myocardial dysfunction (SIMD) is a common complication with high incidence rates in sepsis patients. This study aimed to investigate the roles of miR-210-3p regulating cardiomyocyte apoptosis and mitochondrial associated SIMD pathogenesis.

BACKGROUND Although sepsis is a major health problem, data on sepsis epidemiology are scarce. The aim of this study was to assess the incidence of sepsis, based on clinical findings in all adult patients treated with intravenous antibiotic in all parts of all hospitals in an entire population. METHODS This is a retrospective chart review of patients ≥18 years, living in 2 regions in Sweden, w...

Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection. The development and progression of sepsis is multi-factorial, and affects the cardiovascular, immunological and endocrine systems of the body. The complexity of sepsis makes the clinical study of sepsis and sepsis therapeutics difficult. Animal models have been developed in an effort to create reproduc...