OBJECTIVE To determine the number of employed people in a group of patients with neuromuscular diseases and in 3 separate subgroups (facioscapulo-humeral dystrophy, hereditary motor and sensory neuropathy, and myotonic dystrophy) to investigate any differences in employment status between the patient groups, and to identify factors related to employment status. DESIGN Cross-sectional study. ...

OBJECTIVE The aim of this study was to report the baseline and natural progression of diabetic peripheral neuropathy over 12 months in a large mild-to-moderate neuropathy population. RESEARCH DESIGN AND METHODS Patients from a multicentered trial of zenarestat, an aldose reductase inhibitor, had serial measures of neurologic function, including nerve conduction studies (NCSs), quantitative se...

We assessed pulmonary function in hereditary motor and sensory neuropathy. Fourteen neuropathy patients without spinal deformity (group 1), 14 with spinal deformity (group 2), and 16 individuals with idiopathic spinal deformity (group 3) matched to group 2 for age, height and Cobb angle, were included. Hereditary motor and sensory neuropathy severity was measured with Charcot-Marie-Tooth Neurop...

PURPOSE/OBJECTIVES To assess the validity of neuropathy and neuropathic pain-measurement approaches. DESIGN Cross-sectional measurement study. SETTING Two comprehensive cancer centers in the northeastern United States. SAMPLE 117 patients with cancer in an outpatient setting. METHODS Participants were assessed using the five-component Total Neuropathy Score-reduced (TNSr), the TNSr shor...

BACKGROUND Skin denervation in vasculitic neuropathy has rarely been documented despite frequent manifestations of small-fiber neuropathy including reduced sensitivity and neuropathic pain. Recently, skin biopsy has been established as a new approach to diagnose small-fiber sensory neuropathy. OBJECTIVES To investigate the pathologic features of cutaneous nerves and to evaluate inflammatory v...

Sensory neurons have the capacity to produce, release, and respond to acetylcholine (ACh), but the functional role of cholinergic systems in adult mammalian peripheral sensory nerves has not been established. Here, we have reported that neurite outgrowth from adult sensory neurons that were maintained under subsaturating neurotrophic factor conditions operates under cholinergic constraint that ...

Methods. After institutional review board approval and informed consent, 10 patients with active noninfected venous ulcers or a history of such ulcers (CEAP [ClinicalEtiologic-Anatomic-Pathophysiologic] clinical classification 5 or 6) were recruited. No recruited patient had a history of neuropathy or predisposing conditions for neuropathy. Ten age-, sex-, and weight-matched control patients wi...

Small fiber sensory neuropathy is a common disorder in which progressive degeneration of small-diameter nociceptors causes decreased sensitivity to thermal stimuli and painful sensations in the extremities. In the majority of patients, the cause of small fiber sensory neuropathy is unknown, and treatment options are limited. Here, we show that Bcl-w (Bcl-2l2) is required for the viability of sm...

General characteristics in hypertensive patients, positional sensitivity, and upper airway sensory neuropathy

Significance Paclitaxel is a common chemotherapeutic agent and often causes form of sensory dysfunction termed chemotherapy-induced peripheral neuropathy (CIPN). There no approved therapy to counteract CIPN, although the CIPN symptoms interfere with effective cancer treatment impose long-term health economic burdens for survivors. As chemotherapy still first-line many patients, understanding ba...