The enzymes responsible for the degradation of nitrofuran derivatives in rat small intestinal mucosa were examined in vitro.As a result,it was suggested that the initial reactions in the degradation of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide(AF-2) and 5-nitro-2-furfural semicarbazone(nitrofurazone)are mainly catalyzed by xanthine oxidase , while that of 2-amino-5-[2-(5-nitro-2-fury1)-1-(2-fur...

The reaction of Ni(II) acetate tetra-hydrate with the ligand 4-phenyl-2-(1,2,3,4-tetra-hydro-naphthalen-1-yl-idene)hydrazinecarbo-thio-amide in a 2:1 molar ratio yielded the title compound, [Ni(C16H16N3S)2]·2C4H8O·H2O. The deprotonated ligands act as N,S-donors, forming five-membered metallacycles with the metal ion exhibiting a cis coordination mode unusual for thio-semicarbazone complexes. Th...

In the title thio-semicarbazone compound, C18H18ClN3S, the CN3S residue is almost planar (r.m.s. deviation = 0.0031 Å) and forms dihedral angles of 65.99 (7) and 34.60 (10)° with the phenyl and chloro-benzene rings, respectively; the dihedral angle between the aromatic rings is 85.13 (8)°. The conformation about the C=N bond is Z, and that about the C=C bonds is E. The imine N and ethyl N atoms...

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, Jawaharlal Nehru Marg, New Delhi 110002, India E mail: schandra_00eyahoo.com Department of Chemistry, Mewar University, NH-76 Gangrar Chhittogarh (Raj), India E mail: [email protected] ABSTACT: A series of metal complexes of Cu(II) and Ni(II) having the general composition [M(L)X2] with 2,6 Diacetyl pyridine bis...

The Plasmodium falciparum cysteine protease falcipain-2, one of the most promising targets for antimalarial drug design, plays a key role in parasite survival as a major peptide hydrolase within the hemoglobin degradation pathway. In this work, a series of novel dihydroartemisinin derivatives based on (thio)semicarbazone scaffold were designed and synthesized as potential falcipain-2 inhibitors...