The cell-mediated immune profile induced by a recombinant DNA vaccine was assessed in the simian/HIV (SHIV) and macaque model. The vaccine strategy included coimmunization of a DNA-based vaccine alone or in combination with an optimized plasmid encoding macaque IL-15 (pmacIL-15). We observed strong induction of vaccine-specific IFN-gamma-producing CD8(+) and CD4(+) effector T cells in the vacci...

BACKGROUND Results from clinical trials are usually summarized in the form of sampling distributions. When full information (mean, SEM) about these distributions is given, performing meta-analysis is straightforward. However, when some of the sampling distributions only have mean values, a challenging issue is to decide how to use such distributions in meta-analysis. Currently, the most common ...

With increasing accessibility to Geographical Information Systems (GIS) software, researchers and administrators in public health are increasingly encountering spatially referenced datasets. Inferential interest of spatial data analysis often resides not in the statistically estimated maps themselves, but on the formal identification of “edges” or “boundaries” on the map. Boundaries can be thou...

pML31, a plasmid chimera constructed to contain the replication genes of an Flac plasmid, has been studied by electron microscope methods. Heteroduplex analysis shows that the only F sequence present in pML31 is that with corrdinates 40.3-49.3F. This region has previously been identified as essential for plasmid maintenance. The sequence of pML31, which was derived originally from R6-5, carries...

CONTEXT New methods are being validated to easily evaluate the knee joint position sense (JPS) due to its role in sports movement and the risk of injury. However, no studies to date have considered the open kinetic chain (OKC) technique, despite the biomechanical differences compared to closed kinetic chain movements. OBJECTIVE To analyze the validity and reliability of a digital inclinometer...

It is well known that measurement error in observable variables induces bias in estimates in standard regression analysis and that structural equation models (SEM) are a typical solution to this problem. Often, multiple indicator equations are subsumed as part of the SEM model – allowing for consistent estimation of the relevant regression parameters. In many instances, however, embedding the m...

The halothane muscle/gas partition coefficients at 37 degrees C for 26 samples of eight different muscles from four horses were found to depend significantly on the fat content of the muscle sample with a regression coefficient of 1.913 (SEM 0.109) per per cent ether-extractable fat content. The blood/gas partition coefficients in 24 horses showed a significant dependence on plasma triglyceride...

Transcription of T7 and mutant T3 DNA during infections of F plasmid-containing cells has been analyzed by using Southern hybridization. A transcriptional defect is apparent in these abortively infected cells that is most severe in the class III region of the phage genome. In particular, RNAs that are initiated from the gene 13 promoter are not elongated to give full-length molecules. It is sug...

Familial patterns of the occurrence of breast cancer were studied in a population-based case-control series of black women from the Cancer and Steroid Hormone study. The risks of breast cancer among relatives of breast cancer cases were compared to those of controls who were matched for age and locale. Using the term "proband" to indicate either case or control status, significant predictors of...

The aim of the present study was to evaluate the reliability of the Cartesian Optoelectronic Dynamic Anthropometer (CODA) motion system in measuring the cervical range of motion (ROM) and verify the construct validity of the CODA motion system. A total of 26 patients with cervical spondylosis and 22 patients with anterior cervical fusion were enrolled and the CODA motion analysis system was use...