Rasagiline (N-propargyl-1 (R)-aminoindan) is a novel propargylamine, irreversible, selective monoamine oxidase inhibitor for treatment of Parkinson's disease (PD), a progressive condition associated with degeneration of dopaminergic neurons in the substantia nigra. Rasagiline inhibits striatal dopamine metabolism, thereby providing relief from motor symptoms of PD. It may be dosed once daily an...

The enzymes are mostly proteins and are natural biocatalysts; they catalyze many anabolic and catabolic specific chemical reactions without itself undergoing any change in overall reaction. The temperature, pH, concentration of substrates and enzymes can affect their actions. The enzymes are useful in digestion, coagulation, tissue repair and numerous other life essential processes. The enzyme ...

Neurology® 2009;73:1 A reliable biomarker for HIV-associated dementia (HIV-D) has eluded neuro-AIDS investigators for more than 2 decades. An urgent need remains, because although the incidence of HIV-D has declined among patients treated with highly active antiretroviral therapy, prevalence has increased, and a more insidious cognitive decline, minor cognitive motor disorder (MC/MD), has becom...