BACKGROUND Although grey matter damage in multiple sclerosis is currently recognized, determinants of grey matter volume and its relationship with disability are not yet clear. OBJECTIVES The objectives of the study were to measure grey and white matter volumes across different disease phenotypes; identify MRI parameters associated with grey matter volume; and study grey and white matter volu...

term follow up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis. et al. Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. microarrays identify key mediators of autoimmune brain inflammation. The natural history of mult...

Cumulating evidence points to a key role for CD8+ T cells in the pathogenesis of multiple sclerosis.CD8 expression level was believed to be present constantly on the surface of human peripheral blood T cells. However, it was shown that peripheral blood lymphocytes may be divided by the level of CD8 expression, into CD8+high and CD8+low T cells. Now it is well established that the CD8low populat...

Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS), characterized by myelin loss, axonal pathology and progressive neurodegeneration [1]. Disease starts in 85% of cases with a clinically isolated syndrome (CIS), a first (sub)acute neurological event with demyelination. Different clinical subtypes of MS exist, with 85-90% of patients experiencing relapsingre...

Multiple sclerosis (MS) is a common inflammatory disease of the nervous system that generally starts in young adulthood and over time frequently leads to progressive functional deficits. A characteristic of this still puzzling disease is that its clinical manifestation changes as it progresses. Although during the early phases of the disorder, most patients mainly experience relapses, on averag...

While evoked potentials are sensitive tools for diagnosing multiple sclerosis, little is known about their prognostic value and their role in determining the course of the disease. To validate the visual and motor evoked potentials (VEP and MEP) as measures for the course of multiple sclerosis, we examined prospectively 30 patients with relapsing-remitting or secondary progressive multiple scle...

BACKGROUND Partial blockade of voltage-gated sodium channels is neuroprotective in experimental models of inflammatory demyelinating disease. In this phase 2 trial, we aimed to assess whether the sodium-channel blocker lamotrigine is also neuroprotective in patients with secondary progressive multiple sclerosis. METHODS Patients with secondary progressive multiple sclerosis who attended the N...

Objective(s): Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-7 receptor alpha chain (IL-7Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are tr...

As one of the most common neurological disabilities in young adults, Multiple sclerosis (MS) has characteristics of inflammation, demyelination, neuro-axonal damage, and progressive prolonged disability. The disease is clinically divided into three general categories according to response to treatment: Relapsing-Remitting MS (RRMS), Primary Progressive MS (PPMS) and Secondary Progressive MS (SP...