BACKGROUND Sebaceous carcinoma (SC) is a rare malignancy, occurring predominantly in eyelids. Till date, only 25 cases of sebaceous carcinoma (SC) of the parotid gland have been reported in world literature. CASE PRESENTATION A 33 year-old male presented with left sided laterocervical mass. Clinical examination showed enlargement of the left parotid gland, with cervical lymphadenopathy. No sk...

Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that huma...

Although conjunctival squamous cell carcinoma is known to develop as a result of chronic irritation from wearing an ocular prosthesis, orbital sebaceous gland carcinoma arising in an anophthalmic pocket is extremely rare. We report a 68-year-old female who developed a sebaceous gland carcinoma 65 years after her right eye was enucleated (at the age of three years) due to congenital glaucoma. Th...

BACKGROUND Metastatic extraorbital sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial. MATERIAL AND METHODS Extensive literature search was done, and the treatment options are discussed. RESULTS Results. The...

Syringocystadenoma papilliferum is an uncommon benign apocrine gland tumour, mostly of congenital or early childhood onset, affecting head and neck. In addition, nevus sebaceous is commonly associated with this tumor. Here, we document three cases of syringocystadenoma papilliferum with many atypical features, such as the involvement of rare sites (abdomen, axilla and thigh), absence of nevus s...

BACKGROUND Ocular sebaceous carcinoma can masquerade as benign lesions resulting in delay of diagnosis. Early recognition is even more difficult in young patients where the disease rarely occurs. Here, we provide a clinicopathological correlation of ocular sebaceous carcinoma in a young individual lacking history of hereditary cancer or immunosuppression. FINDINGS A detailed histopathological...

At their ¢rst studies on the physiology and pathophysiology of the skin looking for an adequate ¢eld of future dedication, budding skin researchers usually go quickly through the chapter on the Biology of Sebaceous Glands having obtained the following piece of knowledge: sebaceous glands produce sebum and are partially responsible for acne vulgaris. Seemingly, a limited and less attractive ¢eld...

The human hair follicle (HF) contains multiple follicular melanin units (FMU) consisting of diverse subpopulations melanocytes, defined by their location and level differentiation/melanogenic-acitivty. This includes the infundibulum (In-FMU), stem/bulge (Stem-FMU), sebaceous gland (Sb-FMU), outer root sheath (O-FMU), peripheral proximal bulb (PP-FMU), melanogenically-active region (M-FMU). expr...

We report a sebaceous carcinoma confined to the corneoscleral limbus without involvement of the eyelid. A 60-year-old man, who showed multiple masses on the corneaoscleral limbus and limbal ulceration but with normal eyelids, underwent surgical en-bloc excision of the masses. Histopathologic examination revealed a sebaceous carcinoma. Three weeks after excision, multiple pagetoid recurrences we...

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently un...