نتایج جستجو برای: scf

تعداد نتایج: 3666  

Journal: :The Journal of clinical investigation 1994
L S Rusten E B Smeland F W Jacobsen E Lien W Lesslauer H Loetscher C M Dubois S E Jacobsen

Stem cell factor (SCF), a key regulator of hematopoiesis, potently synergizes with a number of hematopoietic growth factors. However, little is known about growth factors capable of inhibiting the actions of SCF. TNF-alpha has been shown to act as a bidirectional regulator of myeloid cell proliferation and differentiation. This study was designed to examine interactions between TNF-alpha and SC...

2007
Maria Carmen Lemos Lisa Dilling

For the past ten years, the role of seasonal climate forecasting (SCF) in decreasing the vulnerability of poor populations in many countries to climate variability and change has been discussed in the scholarly literature and policy circles. This paper reviews the literature on climate forecasting information and explores three main equity implications of SCF use. First, while investment in SCF...

Journal: :Journal of leukocyte biology 2007
Vladislav Dolgachev Molly Thomas Aaron Berlin Nicholas W Lukacs

Eosinophil activation during allergic diseases has a detrimental role in the generation of pathophysiologic responses. Stem cell factor (SCF) has recently shown an inflammatory, gene-activating role on eosinophils and contributes to the generation of pathophysiologic changes in the airways during allergic responses. The data in the present study outline the signal transduction events that are i...

Journal: :Haematologica 1995
A Grossi A M Vannucchi P Bacci G Longo D Rafanelli R Alterini P Rossi Ferrini

BACKGROUND Stem cell factor (SCF) has already been shown to participate in the regulation of erythro- and granulopoiesis. The aim of this study was to define the possible role of SCF in the regulation of megakaryocytopoiesis. METHODS Stem cell factor activity has been assessed in an in vivo murine model, in which different doses of the factor were either given alone or in association with rec...

2014
JUNLI GUO WEI JIE ZHIHUA SHEN MENGSEN LI YOULING LAN YUEQIONG KONG SHAOLI GUO TIANFA LI SHAOJIANG ZHENG

The transplantation of cardiac stem cells (CSCs) is thought to be responsible for improving the performance of injured heart induced by myocardial infarction (MI). However, the mechanisms involved in the migration of activated CSCs post‑MI remain to be clarified. In this study, CSCs were isolated from rat hearts and a cellular migration assay was performed using a 24‑well Transwell system. Stem...

Journal: :Blood 1999
T Facon J L Harousseau F Maloisel M Attal J Odriozola A Alegre W Schroyens C Hulin R Schots P Marin F Guilhot A Granena M De Waele A Pigneux V Méresse P Clark J Reiffers

Stem cell factor (SCF) has been shown to synergize with filgrastim to mobilize CD34(+) cells into the peripheral blood. To determine if addition of SCF to chemotherapy and filgrastim reduces the number of leukaphereses required to achieve a target yield of 5 x 10(6) CD34(+) cells/kg, 102 patients with multiple myeloma were randomized to receive mobilization chemotherapy with cyclophosphamide (4...

Journal: :Blood 1997
J A Glaspy E J Shpall C F LeMaistre R A Briddell D M Menchaca S A Turner M Lill L Chap R Jones M D Wiers W P Sheridan I K McNiece

The safety and optimal dose and schedule of stem cell factor (SCF) administered in combination with filgrastim for the mobilization of peripheral blood progenitor cells (PBPCs) was determined in 215 patients with high-risk breast cancer. Patients received either filgrastim alone (10 microg/kg/d for 7 days) or the combination of 10 microg/kg/d filgrastim and 5 to 30 microg/kg/d SCF for either 7,...

Journal: :Biological & pharmaceutical bulletin 2013
Da-guang Wang Xi-hui Xu Hui-jun Ma Cheng-rang Li Xue-zhuang Yue Jie Gao Wen-yuan Zhu

In conjunction with matrix proteins, stem cell factor (SCF) plays an important role in the migration of melanocyte precursors (MPs) derived from the mouse embryo. However, no studies have demonstrated an effect of SCF on human follicular MPs migration in vitro. In this report, first we demonstrate the immature state of the follicular MPs. Then cell attachment rate was measured by 3-(4,5-dimethy...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1996
H Zwierzina T Bammer I Rollinger-Holzinger M Herold P Fenaux V Nüssler E Hoflehner D Geissler

Anemia remains a therapeutic problem in patients with myelodysplastic syndrome (MDS). In view of the recently reported potential of stem cell factor (SCF) in restoring erythropoiesis in combination with erythropoietin (Epo), we first aimed to define a correlation between SCF serum levels and anemia in MDS. Endogenous SCF levels in 50 MDS patients were determined by using a quantitative sandwich...

Journal: :Blood 1992
R G Andrews W I Bensinger G H Knitter S H Bartelmez K Longin I D Bernstein F R Appelbaum K M Zsebo

Recombinant human stem cell factor (SCF), the ligand for c-kit, has been shown to stimulate increased numbers of hematopoietic progenitor cells of multiple types to circulate in the blood of baboons, but it was not known if the cells stimulated to circulate by SCF contained cells capable of engrafting and rescuing lethally irradiated baboons. Peripheral blood mononuclear cells (PBMNC) were coll...

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