Traditionally, platelets have been thought of as anuclear, subcellular fragments derived from megakaryocytes circulating in blood as small discs and mitigating hemorrhage. This hemostatic process requires platelet activation, a complex chain of events involving rapid structural changes that activate adhesion receptors, remodel the cytoskeleton, and lead to the eventual synthesis and secretion o...

Background: IgA vasculitis (IgAV) is the most common systemic of childhood, characterized by palpable purpura, arthritis, gastrointestinal and renal involvement 1 . It a relatively self-limited disease apart from which associated with long term morbidity. Objectives: We aimed to define marker at onset predict involvement. Methods: In this pilot study, we analyzed targeted panel vascular inflamm...

BACKGROUND The aim of the study was to compare the effects of 2 strategies of antiplatelet treatment (i.e., 150 mg ASA vs. 75 mg clpoidogrel) on plasma level of inflammatory markers in type 2 diabetes mellitus (T2DM) patients with high platelet reactivity (HPR). METHODS Study cohort consisted of 304 T2DM patients on chronic ASA therapy (75 mg per day) participating in the Aspirin Versus/Or Cl...

INTRODUCTION Fibrates produce additional actions such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, along with stimulation of fibrinolysis. It is not known whether fibrates can attenuate platelet activation. OBJECTIVES Evaluation of antiplatelet effects of fenofibrate in dyslipidemic subjects. PATIENTS AND METHODS In 20 patients (15 males, 5 fem...

OBJECTIVE To evaluate the predictive value of seven biomarkers, which individually have been shown to be independent predictors, for use in a combined multimarker model for long-term cardiovascular outcome after non-ST-segment elevation acute coronary syndrome (NSTEACS). DESIGN AND SETTING Levels of high-sensitivity C-reactive protein (hsCRP), myeloperoxidase, pregnancy-associated plasma prot...