BACKGROUND Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs. METHODS We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Parti...

BACKGROUND Leukoaraiosis, microbleeds, and silent brain infarctions are phenotypes of small vessel disease. Leukoaraiosis is the most prevalent, and advanced periventricular leukoaraiosis is regarded as a strong predictor of cognitive dysfunction. Microbleeds and silent brain infarctions sometimes coexist with leukoaraiosis. This study aims to analyze the effects of microbleeds and silent brain...

Staphylococcus aureus, a pathogen responsible for hospital and community-acquired infections, expresses many virulence factors under the control of numerous regulatory systems. Here we show that one of the small pathogenicity island RNAs, named SprD, contributes significantly to causing disease in an animal model of infection. We have identified one of the targets of SprD and our in vivo data d...

BACKGROUND As alcohol-related health problems continue to rise, the attention of policy-makers is increasingly turning to Screening and Brief Intervention (SBI) programmes. The effectiveness of such programmes in primary healthcare is well evidenced, but very few cost-effectiveness analyses have been conducted and none which specifically consider the Italian context. METHODS The Sheffield Alc...

OBJECTIVE To assess factorial validity and internal consistency of the Brazilian version of the 'Spanish Burnout Inventory' (SBI). METHODS The translation process of the SBI into Brazilian Portuguese included translation, back translation, and semantic equivalence. A confirmatory factor analysis was carried out using a four-factor model, which was similar to the original SBI. The sample consi...

BACKGROUND A prior study (N Engl J Med. 1993; 329: 1437-1441) produced an effective screen to identify 1-to 2-month-old febrile infants (FIs) who are at low risk of having a serious bacterial illness (SBI). Because of anticipated differences in the epidemiological features of febrile illnesses, that Philadelphia protocol was not applied to FIs younger than 1 month. OBJECTIVES To describe the ...

There is evidence for the effectiveness of screening and brief intervention (SBI) for risky alcohol and other drug use when administered by trained health professionals. However, there have been no controlled studies on the implementation of BI techniques when health professionals were trained by a distance learning (DL) process. In this study, we evaluated the use of SBI by health professional...

Introduction and aim. Fever is a common complaint for children addressing the emergency departments (ED). Distinguishing between febrile children with self limited viral infection and those with serious bacterial infection (SBI) may be challenging for practitioners, especially in younger population. Recently, a laboratory score, named the Lab-score, combining Procalcitonin, C-reactive protein a...

BACKGROUND Screening and brief interventions (SBI) for alcohol related problems have been shown to be effective in health settings such as general practice or emergency departments. Recent data from the United Kingdom and New Zealand suggest that SBI can be delivered through community pharmacies, but this approach has not been tested in Australia. This study assesses the feasibility of deliveri...

OBJECTIVES To compare the diagnostic properties of procalcitonin (PCT), C reactive protein (CRP), total white blood cells count (WBC), absolute neutrophil count (ANC) and clinical evaluation to detect serious bacterial infection (SBI) in children with fever without source. DESIGN Prospective cohort study. SETTING Paediatric emergency department of a tertiary care hospital. PARTICIPANTS Ch...