Efficacy, safety, and pharmacokinetics results from 4 studies-3 open-label (OL) and 1 randomized double-blind (DB)-have provided data for approval of etanercept for treatment of disease-modifying anti-rheumatic drug (DMARD)-refractory juvenile idiopathic arthritis (JIA) in Japan. Results from the 3 shorter-term (2 OL and 1 DB) studies are reported here. Subjects (4-17 years) enrolled in the OL ...

BACKGROUND Periventricular white matter injury (PWMI) is a common form of brain injury sustained by preterm infants. A major factor that predisposes to PWMI is hypoxia. Because oligodendrocytes (OLs) are responsible for myelination of axons, abnormal OL development or function may affect brain myelination. At present our understanding of the influences of hypoxia on OL development is limited. T...

Volatile organic compounds in farmed and wild rohu, Labeo rohita, were extracted by Likens-Nickerson concurrent distillation apparatus. The farmed raised rohu of two weight categories designated as FW1 (1001-1200g) and FW2 (501-700g) were procured from the Fish Seed Hatchery, Faisalabad. Concurrently, wild rohu of two weight categories designated as WW1 (1001-1200g) and WW2 (501-700g) were capt...

In the present study a various phytochemical compounds that have been isolated from Melia azedarach and showed phytoconstituents leaves against three of pathogenic fungi are as follows: Alternaria alternate, Neoscytalidium dimidiatum Sordaria fimicola. ''The Phytochemical M. were exposed to (GC-MS) analysis. The results highest activity reviewed fungal, (Alternaria fimicola). All concentrations...

AIMS This study looks to assess the oral health status in the study subjects and to quantify the prevalence of WHO defined HIV-related oral stage 3 and 4 lesions (HIV-OL) as those conditions are indicating need for treatment independently of CD4 count. METHODS This quantitative screening study used both structured questionnaire and clinical examination to determine the prevalence of HIV-OL in...

In the past decades, there has been great progress in development of organic and inorganic optical limiters with large nonlinear optical (NLO) response. Carbon-based materials, including carbon black suspension (CBS), singleand multi-walled carbon nanotubes (CNTs), 3] and some small p-electron systems, such as fullerenes, porphyrins, and phthalocyanines have been widely explored as advanced opt...

Multiple sclerosis (MS) is an autoimmune mediated neurodegenerative disease characterized by demyelination and oligodendrocyte (OL) loss in the central nervous system and accompanied by local inflammation and infiltration of peripheral immune cells. Although many risk factors and symptoms have been identified in MS, the pathology is complicated and the cause remains unknown. It is also unclear ...

Este trabalho teve como objetivo a avaliação das características agronômicas e mercadológicas de genótipos amendoim na mesorregião nordeste do estado Mato Grosso. O experimento foi desenvolvido no ano agrícola 2021/22, Fazenda Santo Antônio, localizado município Antônio Leste-MT. delineamento experimental em blocos casualizados, com quatro repetições. Os tratamentos foram dez rasteiro, sendo um...

Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and their absolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and (S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker's yeast. Lipase-mediated esterifications and hydrolysis of the corresponding racemic substrates gave rise to the enantiopure compounds (1S,2R)-2-benzylin...

The response of the two most abundant cockchafer species in central Europe, Melolontha hippocastani and M. melolontha, towards phenol, mixtures of phenol with the leaf alcohol (Z)-3-hexen-1-ol and the known cockchafer pheromones, 1,4-benzoquinone (M. hippocastani) and toluquinone (M. melolontha), was investigated in the field. During the swarming period at dusk, phenol attracted males of both s...