BACKGROUND Stroke-associated pneumonia (SAP) has been implicated in the morbidity, mortality and increased medical cost after acute ischemic stroke. The annual cost of SAP during hospitalization in the United States approaches USD 459 million. The incidence and prognosis of SAP among intensive care unit (ICU) patients have not been thoroughly investigated. We reviewed the pathophysiology, micro...

BACKGROUND Systemic antibiotic prophylaxis (SAP) for combat wounds is controversial. Current military practice favors its use, despite scant supporting evidence. OBJECTIVE To analyze outcomes of combat casualties returned to duty after initial wound care for penetrating trauma, comparing infection rates based on whether SAP was administered and whether wounds were irrigated. SETTING Forward...

Pepys and coworkers report in a recent paper (Bodin et al., Nature 2010; 468:93–97 [1]), the rapid resorption of visceral amyloid using antibodies to a common constituent of all amyloid deposits, the serum amyloid P component (SAP), in a human SAP transgenic mice model of reactive amyloidosis (AA amyloidosis) [1]. SAP binds avidly to all types of amyloid fibrils and protects them from proteolyt...

Severe acute pancreatitis (SAP) is a disease usually associated with systemic organ dysfunction or pancreatic necrosis. Most patients with SAP suffer from defective intestinal motility in the early phase of the disease. Additionally, SAP-induced inflammation produces hydrogen sulphide (H2S) that impairs the gastrointestinal (GI) system. However, the exact mechanism of H2S in the regulation of S...

BACKGROUND Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and anti-inflammation. The aim of the current study is to investigate the role of HO-1 on systemic inflammatory response in severe acute pancreatitis (SAP). METHODS Forty male Sprag...

BACKGROUND Stroke-associated pneumonia (SAP) is common in patients with acute ischemic stroke, and several risk factors have been reported. However, the relationship between underlying leukoaraiosis (LA) and SAP has not been addressed. METHODS We collected consecutive patients with acute ischemic stroke within 24 h of symptom onset. SAP was defined as the lower respiratory tract infection wit...

Objective: This study aimed to investigate the value of the neutrophil CD64 index for diagnosing secondary infection in Severe Acute Pancreatitis (SAP) patients. Methods: A total of 43 patients with SAP were enrolled between January 2011 and December 2015. Patient Acute Physiology and Chronic Health Evaluation II and Rason scores were calculated and blood samples were collected to determine the...

OBJECTIVE To examine the effects of crossing over from optimized multiple daily injection (MDI) therapy to sensor-augmented pump (SAP) therapy for 6 months, and the effects of 18 months' sustained use of SAP. RESEARCH DESIGN AND METHODS The 6-month, single-crossover continuation phase of Sensor-Augmented Pump Therapy for A1C Reduction (STAR 3) provided SAP therapy to 420 subjects who completed...

The lysosomal degradation of ceramide is catalyzed by acid ceramidase and requires sphingolipid activator proteins (SAP) as cofactors in vivo. The aim of this study was to investigate how ceramide is hydrolyzed by acid ceramidase at the water-membrane interface in the presence of sphingolipid activator proteins in a liposomal assay system. The degradation of membrane-bound ceramide was signific...