background: visceral leishmaniasis is caused by leishmania infantum , transmitted to humans by bites of phle­botomine sand flies and is one of the most important public health problems in iran. to identify the vector(s), an investiga­tion was carried out in bilesavar district, one of the important foci of the disease in ardebil province in northwest­ern iran, during july - september 2008 . meth...

Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b, and C9b on agarose-coated plates in a dose-dependent manner. It also inhibited the activation of ...

BACKGROUND Tsetse flies are obligate blood-feeding insects that transmit African trypanosomes responsible for human sleeping sickness and nagana in livestock. The tsetse salivary proteome contains a highly immunogenic family of the endonuclease-like Tsal proteins. In this study, a recombinant version of Tsal1 (rTsal1) was evaluated in an indirect ELISA to quantify the contact with total Glossin...

BACKGROUND Canine Visceral Leishmaniasis (CVL) is a zoonotic disease caused by Leishmania infantum, transmitted by the bite of Lutzomyia longipalpis sand flies. Dogs are the main domestic reservoir of the parasite. The establishment of an experimental model that partially reproduces natural infection in dogs is very important to test vaccine candidates, mainly regarding those that use salivary ...

This work had the objective of listing the sand fly species that occur in the State of Mato Grosso, Brazil. Data relating to entomological surveys conducted between 1996 and 2004 were obtained from the National Health Foundation and the State Health Department, and this was supplemented with information from research carried out in the state and from the specialized literature. There were recor...

array of antihemostatic chemicals (Ribeiro, 1987, 1995), including anticlotting, antiplatelet and vasodilatory substances. Interestingly, the solutions found by each arthropod species to counteract each aspect of their host hemostasis are very different, perhaps as a result of evolutionary convergence. For example, vasodilators found in the saliva or salivary homogenates of such animals include...

Morphological description of sand,flies has remained a neglected area. The different organs used in taxonomy have not yet been described adequatelAy with the scanning electron microscopy (SEM). We have examined the external genital structures offemales of three Old World phlebotomine sand,flies under SEMand recorded the morphological variations of the organs. We have,found the,female external g...

The repellent action of neem oil was evaluated against sand flies under laboratory and field conditions. Concentrations of 2% neem oil mixed in coconut or mustard oil provided 100% protection against Phlebotomus argentipes throughout the night under field conditions; against Phlebotomus papatasi it repelled sand flies for about 7 h in the laboratory. Neem oil is an indigenous product and a low-...

Reducing populations of phlebotomine sand flies in areas prevalent for human leishmaniases is of ongoing importance to United States military operations and civilian populations in endemic regions. However, not enough is known regarding the efficacy of Department of Defense-approved pesticides and equipment against sand flies; specifically, the potential for ultra-low volume (ULV) pesticide app...