Purpose: To examine the effects and mechanisms of transient activation of the Hedgehog pathway on rescuing radiotherapy-induced hyposalivation in survivors of head and neck cancer. ExperimentalDesign:Mouse salivary glands and cultured human salivary epithelial cells were irradiated by a single 15-Gy dose. TheHedgehog pathwaywas transiently activated inmouse salivary glands, by briefly overexpre...

www.johronline.com 83 | P a g e For Correspondence: [email protected] Received on: September 2014 Accepted after revision: October 2014 Downloaded from: www.johronline.com Introduction Sialolithiasis is a common disorder of salivary glands, it is a condition characterized by the obstruction of a salivary gland or its excretory duct due to formation of sialolith, further resulting in i...

In this study we tested the use of salivary cortisol and cortisone as alternatives to serum cortisol. Salivary cortisol is often undetectable and contaminated by hydrocortisone. Salivary cortisone strongly reflects serum cortisol.

Introduction: Chronic sclerosing sialadenitis is a relatively uncommon disorder of the salivary gland. Because of its clinical similarity to a salivary gland neoplasm, this condition has been known as Kuttner tumor and is classified as a tumorlike lesion. Case Report: This is the first reported case of bilateral Kuttner tumor of the submandibular glands in Iran. It was initially diagnosed as...

Estrogen receptors (ERs) expression has been studied in salivary gland tumors, however, there are conflicting results regarding its expression in the literatures. The aim of this study was to investigate the expression of estrogen receptors protein (ERs) in pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) of salivary glands using immunohistochemistry. 35 cases of intraoral minor sali...

Salivary gland bioengineering requires understanding the interaction between salivary epithelium and surrounding tissues. An important component of salivary glands is the presence of neurons. No previous studies have investigated how neurons and salivary epithelial cells interact in an in vitro co-culture model. In this study, we describe the self-organization of neurons around salivary epithel...

AIM To determine the influence of inflammation on salivary secretion. Secretion by salivary glands involves interactions between nerves, blood vessels and salivary cells. The present study investigated the effects of inflammation on rat submandibular gland function following acute ductal obstruction. METHODS Under recovery anaesthesia a metal clip was placed on the main duct of the submandibu...

BACKGROUND Fermentable carbohydrates and microorganisms in the plaque play a significant role in the pathogenesis of dental caries. Oral clearance of sugars and salivary pH is affected by the presence of plaque. AIMS AND OBJECTIVES This study was conducted to study the effect of the presence of plaque on the salivary clearance of sucrose and on salivary pH. MATERIALS AND METHODS The study d...

[Purpose] The purpose of this study was to clarify the validity of salivary α-amylase as a method of quickly estimating anaerobic threshold and to establish the relationship between salivary α-amylase and double-product breakpoint in order to create a way to adjust exercise intensity to a safe and effective range. [Subjects and Methods] Eleven healthy young adults performed an incremental exerc...

OBJECTIVES The aim of this study was to evaluate 8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in whole saliva of patients with chronic periodontitis. Moreover, the relationship among the oxidative damage biomarkers, antioxidant enzymes activities and clinical periodontal status were investigated. ...