The family of calgranulins includes S100A8 (calgranulin A), S100A9 B), which can appear as a heterodimer known S100A8/A9 or calprotectin, and S100A12 C). These proteins are related to different inflammatory conditions, immune-mediated diseases, sepsis considered biomarkers potential interest. This study aims evaluate if A12 could change in pigs with diarrhea due E. coli compare the changes othe...

Background Antibodies against double stranded DNA (anti-dsDNA) can induce production of interferon-alpha and other cytokines after forming immune complexes. In SLE, anti-dsDNA often exists together with autoantibodies chromatin components, like histones nucleosomes. These antibodies are known to characterize a SLE subgroup early disease onset increased occurrence nephritis. Objectives We invest...

Previously, we examined the prognostic utility of skin microbiome-based stratification for atopic dermatitis (AD) and defined steady-state microbial configurations (“dermotypes”) that classified patients by clinical severity, cutaneous barrier properties IgE status. Here, explored circulating immune dysregulation underlying microbiome-stratified AD to elucidate heterogeneity in profiles. Using ...