Atherosclerosis is a complex disease whose pathogenesis includes endothelial activation, accumulation of lipids in the subendothelium, formation foam cells, fat bands and atherosclerotic plaque. These mechanisms involve different cell populations intimate sub-endothelium, S-100 protein family plays role number extracellular intracellular processes during development lesions. The aim this study ...

Roberto MONTALTI*, Gianluca ROMPIANESI, Francesca PEGORARO, Mariano GIGLIO, Giuseppe DE SIMONE, Pietro VENETUCCI, TROISI. Ann Hepatobiliary Pancreat Surg 2023;27:S100. https://doi.org/10.14701/ahbps.2023S1.OP-6-6

Abstract The receptor for advanced glycation end products (RAGE), a pattern recognition receptor, plays role in chronic inflammation. Abrogation of proinflammatory RAGE signaling by ligand binding (e.g., S100/calgranulins) to soluble decoy (sRAGE) is promising novel therapeutic avenue inflammatory diseases, such as bowel disease (IBD). However, the opportunities studying S100/calgranulin-RAGE p...

Introduction Systemic onset Juvenile Idiopathic Artritis (sJIA) is considered to be an autoinflammatory disease. The S100-proteins S100A8, S100A9 and S100A12 in serum and interleukin (IL)-18 in plasma are extremely elevated in sJIA patients and have been proposed to be useful biomarkers for diagnosis, disease activity and response to therapy. Moreover, sJIA patients seem to have a defective IL-...

PURPOSE Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration, proliferation, and differentiation. The aim of this study was to investigate the presence o...

Novel immune-related targets hold promise to improve melanoma treatment and patient survival. Using bioinformatics, we previously identified 21 molecules differentially expressed in metastatic have significant correlation with We shortlisted five candidate that been implicated pathogenesis of other cancer types, however, none has explored melanoma. These are (i) MZB1, a B cell-specific cochaper...