BACKGROUND Genetic polymorphism was hypothesized to be reason of variation in prostate cancer incidence among different racial group. Based on that published data on the association of prostate cancer susceptibility with polymorphisms in genes encoding Glutathione S-transferases (GSTs) were inconclusive, the aim of this study was to more precisely address the role of GSTs polymorphisms (especia...

AIM We aimed to study the potential role of GSTM1 and GSTT1 in the risk of osteosarcoma in Chinese population. METHODS We collected 110 osteosarcomas by pathologic examination and 226 controls from the First Affiliated Hospital of Harbin Medical University during December 2008 to December 2010. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method. RESULTS Indi...

MOTIVATION The occurrence of false positives and false negatives in a microarray analysis could be easily estimated if the distribution of p-values were approximated and then expressed as a mixture of null and alternative densities. Essentially any distribution of p-values can be expressed as such a mixture by extracting a uniform density from it. RESULTS The occurrence of false positives and...

Hybrid methodology involving differential equations modeling and statistical regression is developed in order to test basic ideas in asset price dynamics. In particular, the method provides a mechanism for testing the relative importance of price trend compared with valuation. The significance of yearly highs in prices can also be understood through this procedure. A large data set of 52 closed...

When ACL2 is used to model the operational semantics of computing machines, machine states are typically represented by terms recording the contents of the state components. When models are realistic and are stepped through thousands of machine cycles, these terms can grow quite large and the cost of simplifying them on each step grows. In this paper we describe an ACL2 book that uses HIDE and ...

In order to meet the individualization needs, software manufacturing companies have developed a number of individualized services. However, it leads to a lot of redundant software products and low production efficiency. In addition, it cannot quickly and efficiently respond to changes in demand. In order to solve above problems, the concept of configurable process model was proposed. Given a co...

O-GlcNAcylation is an abundant posttranslational modification in the brain implicated in human neurodegenerative diseases. We have exploited viable null alleles of the enzymes of O-GlcNAc cycling to examine the role of O-GlcNAcylation in well-characterized Caenorhabditis elegans models of neurodegenerative proteotoxicity. O-GlcNAc cycling dramatically modulated the severity of the phenotype in ...

In the present research, we argue that there are two distinct types of mortality salience, namely mortality salience of self (MSS) which is awareness of one’s own death and mortality salience of a loved one (MSLO) which is awareness of the death of a loved one. Studies based on Terror Management Theoryhave assumed that MSLO individuals’ response might follow predictably from the perspective of ...

INTRODUCTION Endovascular coiling of aneurysms crossing the Circle of Willis has been described in small case series. The technical challenges in manipulating a stent across the Circle of Willis lie in negotiating difficult angles and small arteries. We present our experience with treating aneurysms by stent assistance in which the Circle of Willis was crossed to facilitate optimal stent deploy...