ABSTRACTParkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of PD in rat. For this purpose, unilateral ...

background:  assessment  of quality-of-life (qof) as  an outcome   measure   after  deep   brain  stimulation   (dbs) surgery in patients  with parkinson’s disease  (pd) need  a valid, reliable and responsive  instrument. the aim of the current   study   was   to   determine   responsiveness   of validated  persian  version  of pd questionnaire  with  39- items (pdq-39) after dbs surgery in pat...

—Determining neuronal structures during stereotactic surgery in Parkinson’s disease (PD) patients is a prerequisite for optimal placement of deep brain stimulation electrodes and/or neuronal ablation. This study describes statistical signal processing methods that automatically analyze microelectrode recordings and display a neurophysiological brainmap of the stereotactic trajectory. The sponta...

Background Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only proteins associated with risk but also pathways that play role in aging. Objective To evaluate phenotype-modifying effects genetic variants Klotho, longevity gene. Methods We analyzed two longitudinal cohorts:...

Background: Parkinson’s disease (PD) is one of the most common neurodegenerative diseases (ND). Studies have demonstrated that biochemical markers have an association with PD. We aimed to investigate an association of biochemical markers including calcium, vitamin D, alkaline phosphatase (ALP), parathormone (PTH), and phosphorous with PD. Methods: This study was conducted on 139 PD patients an...

Abstract Background The Needs Assessment Tool: Progressive Disease-Heart Failure (NAT: PD-HF) is a tool created to assess the needs of people living with heart failure and their informal caregivers assist delivering care in more comprehensive way that addresses actual are unmet, improve quality life. In this study, we aimed (1) Translate into German culturally adapt it. (2) Assess internal cons...

Objective(s): Exercise ameliorates the quality of life and reduces the risk of neurological derangements such as Alzheimer’s (AD) and Parkinson’s disease (PD). Irisin is a product of the physical activity and is a circulating hormone that regulates the energy metabolism in the body. In the nervous system, Irisin influences neurogenesis and neural differentiation in mic...

Mutations in the parkin gene cause autosomal-recessive, juvenile-onset parkinsonism, and parkin dysfunction may also play a role in the pathogenesis of sporadic Parkinson disease (PD). Although its precise function remains largely unknown, parkin seems to play a neuroprotective role. Several studies indicate that changes in parkin solubility induced by post-translational modifications, such as ...

OBJECTIVE Parkinson(')s disease (PD) is one of the most common neurodegenerative disorders which is characterized by tremor, rigidity, bradykinesia and postural disturbances. Studies indicate that grape juice and exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of red grape juice (GJ) together with treadmill running o...

BACKGROUND Neurological assessment of a patient with Parkinson's disease (PD) is expected to reflect upon functional performance. As women are known to report more limitations even for same observed functional performance level, present study was designed to examine whether associations between neurological assessments and functional performance differ across genders. METHODS 14 men and 14 wo...