نتایج جستجو برای: rpos

تعداد نتایج: 1053  

Journal: :Genetics 2010
Sanna Koskiniemi Diarmaid Hughes Dan I Andersson

It has been suggested that bacteria have evolved mechanisms to increase their mutation rate in response to various stresses and that the translesion DNA polymerase Pol IV under control of the LexA regulon and the alternative sigma factor RpoS are involved in regulating this mutagenesis. Here we examined in Salmonella enterica serovar Typhimurium LT2 the rates for four different types of mutatio...

2013
Chin-Yi Chen Christopher S. Hofmann Bryan J. Cottrell Terence P. Strobaugh Jr George C. Paoli Ly-Huong Nguyen Xianghe Yan Gaylen A. Uhlich

The biofilm life style helps bacteria resist oxidative stress, desiccation, antibiotic treatment, and starvation. Biofilm formation involves a complex regulatory gene network controlled by various environmental signals. It was previously shown that prophage insertions in mlrA and heterogeneous mutations in rpoS constituted major obstacles limiting biofilm formation and the expression of extrace...

2011
Zhiming Ouyang Ranjit K. Deka Michael V. Norgard

In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ factor, σ(S) (RpoS) which, in turn, controls the expression of virulence-associated membrane lipoproteins. As is customary in σ⁵⁴-dependent gene control, a putative NtrC-like enhancer-binding protein, Rrp2, is required to activate the RpoN-RpoS...

1998
Peter C. Loewen Bei Hu Jeanna Strutinsky Richard Sparling

In Escherichia coli, the transcription factor σS, encoded by rpoS, controls the expression of a large number of genes involved in cellular responses to a diverse number of stresses, including starvation, osmotic stress, acid shock, cold shock, heat shock, oxidative DNA damage, and transition to stationary phase. A list of over 50 genes under the control of rpoS has been compiled. The transcript...

Journal: :Journal of bacteriology 2004
Kyung-Je Park Min-Jin Kang Songhee H Kim Hyun-Jung Lee Jae-Kyu Lim Sang Ho Choi Soon-Jung Park Kyu-Ho Lee

A gene homologous to rpoS was cloned from a fatal human pathogen, Vibrio vulnificus. The functional role of rpoS in V. vulnificus was accessed by using an rpoS knockout mutant strain. This mutant was impaired in terms of the ability to survive under oxidative stress, nutrient starvation, UV irradiation, or acidic conditions. The increased susceptibility of the V. vulnificus mutant in the expone...

2016
Sucharat Sanongkiet Saranyoo Ponnikorn Rachanee Udomsangpetch Sumalee Tungpradabkul

Burkholderia pseudomallei is an intracellular Gram-negative bacterial pathogen and the causative agent of melioidosis, a widespread disease in Southeast Asia. Reactive nitrogen, in an intermediate form of nitric oxide (NO), is one of the first lines of defense used by host cells to eliminate intracellular pathogens, through the stimulation of inducible nitric oxide synthase (iNOS). Studies in p...

Journal: :SIAM J. Applied Dynamical Systems 2009
Claudia Wulff Frank Schilder

Relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur for example in celestial mechanices, molecular dynamics and rigid body motion. RPOs are solutions which are periodic orbits of the symmetry-reduced system. In this paper we analyze certain symmetry-breaking bifurcations of Hamiltonian relative periodic orbits and show how they can be detected and computed ...

Journal: :Journal of bacteriology 1998
C A Whistler N A Corbell A Sarniguet W Ream J E Loper

Three global regulators are known to control antibiotic production by Pseudomonas fluorescens. A two-component regulatory system comprised of the sensor kinase GacS (previously called ApdA or LemA) and GacA, a member of the FixJ family of response regulators, is required for antibiotic production. A mutation in rpoS, which encodes the stationary-phase sigma factor sigmaS, differentially affects...

Journal: :Journal of biochemistry 2006
Ching-Ting Lin Hwei-Ling Peng

In Klebsiella pneumoniae CG43, deletion of the sensor gene kvgS reduced the kvgAS expression in M9 medium with 0.2 mM paraquat, 0.2 mM 2,2-dihydropyridyl, or 300 mM NaCl. This result shows an autoregulatory role of KvgS and a stress-responsive expression of the two-component system (2CS). The kvgS deletion also appeared to decrease the expression of kvhAS, paralogous genes of kvgAS. Additionall...

Journal: :Journal of bacteriology 2004
Anisia J Silva Jorge A Benitez

Vibrio cholerae secretes a Zn-dependent metalloprotease, hemagglutinin/protease (HA/protease), which is encoded by hapA and displays a broad range of potentially pathogenic activities. Production of HA/protease requires transcriptional activation by the quorum-sensing regulator HapR. In this study we demonstrate that transcription of hapA is growth phase dependent and specifically activated in ...

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