PURPOSE (1) Investigation of dependence between first symptoms of the rosacea and with surviving of critical life events. (2) Description of the dissimilarity in intensity of the stress at illness and healthy. (3) Estimation of impact of stressful situations for escalating of changes in course of the disease. (4) Comparison of the subjective estimation of patients' health. MATERIAL AND METHOD...

14.3 (6.7) days (range, 7-20 days) for BT-A. Anhidrotic areas developed earlier in the BT-B side. Patients reported longer-lasting subjective benefit from BT-B than BT-A: 17.3 (7.4) weeks vs 12.9 (8.4) weeks. All patients tolerated intradermally injected BT-A and BT-B well, although some experienced mild pain, especially during BT-B injections. No hematomas developed at the injection site, nor ...

Rhinophyma may have been first recognized in ancient Greece and Arabia.1,2 Elliott et al. and Matton et al. credit Hebra with naming the disease in the mid-nineteenth century.3,4 The name is derived from the Greek rhis, for nose, and phyma, meaning growth. Many imaginative terms have been used to describe the erythematous, hypertrophied, and inflamed nose that typifies rhinophyma. In the past, ...

The purpose of this study was to study changes in glycosylation in tear and saliva obtained from control and ocular rosacea patients in order to identify potential biomarkers for rosacea. Tear fluid was collected from 51 subjects (28 healthy controls and 23 patients with ocular rosacea). Saliva was collected from 42 of the same subjects (25 controls and 17 patients). Pooled and individual sampl...

OBJECTIVE The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA)...

BACKGROUND Rosacea is a common, chronic dermatosis that requires long-term therapy. Oral isotretinoin and topical and/or oral antibiotics are effective, but their usage may be limited due to side-effects. OBJECTIVE The goal of the study was to compare the efficacy of topical adapalene gel (0.1%) and topical metronidazole gel (0.75%) in the treatment of patients with papulopustular rosacea. ...

A growing body of literature suggests that some moisturizers can improve stratum corneum barrier function, as well as ameliorate dry skin. The clinical signs and symptoms of rosacea, which include increased facial skin dryness and sensitivity, suggest a possible role for such moisturizers as an adjuvant in the management of this condition. This randomized, investigator-blind, controlled observa...

BACKGROUND Rebound erythema secondary to use of topical brimonidine in the setting of rosacea is an important, possibly significantly distressing potential side effect that may be under-reported; there is little photo-documentation in the literature to date. This article documents such a case. OBSERVATIONS A 28-year-old woman (Fitzpatrick II) with a long-standing history of untreated rosacea ...

PURPOSE The purpose of this study is to describe a case of ocular rosacea with a very complex evolution. Rosacea is a chronic dermatological disease that may affect the ocular structures up to 6-72% of all cases. This form is often misdiagnosed, which may lead to long inflammatory processes with important visual consequences for affected patients. Therefore, an early diagnosis and an adequate t...