Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and inadequate capacity to block detrimental rt-PA activity in brain endothelial cells (BECs), selecti...

This research work presents a case study of rock mass characterization on diversion tunnels at Diamer Basha Dam, Pakistan. Geological and geotechnical studies were performed to characterize the rock mass along the axis of diversion tunnel. The core specimens retrieved were tested in laboratory and physical and mechanical properties of the rock mass were determined. Detailed discontinuity survey...

In underground tunnels or caverns, time-dependent deformation or failure of rock mass, such as extending cracks, gradual rock falls, etc., are a costly irritant and a major safety concern if the time-dependent damage of surrounding rock is serious. To understand the damage evolution of rock mass in underground engineering, an in situ experimental testing was carried out in a large belowground t...

Original scientific paper Rock generally contains various micro-cracks, fissures, pores, joints, and other defects. These defects affect the mechanical properties of rock. In order to clarify the influence of native fissures on rock deformation and failure modes, a laboratory study was carried out using the fissured dolomite, and acoustic wave velocity measurement and natural water absorption t...

Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the eleva...

Drilling of large-diameter boreholes is regarded as an effective measure for rockburst prevention. By investigating the morphological characteristic and evolution plastic zone in borehole surrounding rock, pressure-relief mechanism was ascertained, engineering application assessed 13230 working face Gengcun Coal Mine, Henan Province, China. The results showed that (1) rock appear circular, elli...

In order to study the laws of crack evolution in rock and explain its fracture instability mechanism, a series laboratory tests were carried out with Jinping Marbles. The test results show that failure degree marbles under unloading conditions is more severe than loading conditions. Based on volume strain, five progressive stages different are divided, corresponding characteristic stresses dete...

The multiscale rock physics of unconventional reservoirs have drawn increasing attention in recent years, which involves several essential issues, including measuring method, transport property, model, characteristic scale, and their application. These issues vastly affect science engineering regarding the exploration development reservoirs. To encourage communication on advances research reser...

The paper presents the numerical simulation of an underground excavation in Callovo-Oxfordian argillaceous formation, performed Meuse/Haute-Marne research laboratory, within context deep geological nuclear waste disposal. constitutive model adopted incorporates a number characteristic features hydromechanical behaviour claystone, and other indurated clays, including anisotropy time-dependent de...