OVERVIEW: Silicon semiconductor (MOSFET: metal-oxide semiconductor field-effect transistor) dimensions are approaching the nanometer scale. The gate electrode size has already been reduced to 50 nm or less for the most advanced 90-nm technology nodes, and for the 65-nm nodes the size is expected to be 25 nm. A new guideline to replace the scaling rule is needed, and making use of the strain eff...

This multisite investigation assessed subjective, behavioral, and objective balance function in 30 blast survivors. Subjects with vertigo, dizziness, or imbalance were screened (n = 6) or evaluated (n = 27) during 1 year. Tests included a questionnaire, electronystagmography (ENG), and computerized dynamic posturography (CDP). Ninety-seven percent of subjects were located inside a building duri...

OBJECTIVE Describe findings observed in ENG of patients with spinocerebellar ataxias. METHOD Forty-three patients were studied, and the following procedures were carried out: anamnesis, otorhinolaryngological and vestibular evaluation (ENG). RESULTS The clinical findings in the entire group of patients were: gait disturbances (83.72%), speech difficulties (48.83%), dizziness (41.86%) and dy...

Accurate regulation of dermal fibroblast function plays a crucial role in wound healing. Many fibrotic diseases are characterized by a failure to conclude normal tissue repair and the persistence of fibroblasts inside lesions. In the present study we demonstrate that endoglin haploinsufficiency promotes fibroblast accumulation during wound healing. Moreover, scars from endoglin-heterozygous (En...

The Wnt (wingless) family of secreted glycoproteins initiates a signalling pathway implicated in the regulation of both normal mouse mammary gland development and tumorigenesis. Multiple Wnt signals ultimately converge on the multifunctional protein beta-catenin to activate the transcription of target genes. Although beta-catenin plays a crucial role in canonical Wnt signalling, it also functio...

Among the possible interfaces with the peripheral nervous system (PNS), intraneural electrodes represent an interesting solution for their potential advantages such as the possibility of extracting spikes from electroneurographic (ENG) signals. Their use could increase the precision and the amount of information which can be detected with respect to other processing methods. In this study, in o...

BACKGROUND Vascular patterning depends on coordinated timing of arteriovenous specification of endothelial cells and the concomitant hemodynamic forces supplied by the onset of cardiac function. Using a combination of 3D imaging by OPT and embryo registration techniques, we sought to identify structural differences between three different mouse models of cardiovascular perturbation. RESULTS E...

The analysis of optokinetic nystagmus (OKN) provides valuable information about the condition of human vision system. One of the phenomena that is used in the medical diagnosis is optokinetic nystagmus. Nystagmus are voluntary or involuntarily eye movements being a response to a stimuli which activate the optokinetic systems. The electronystagmography (ENG) signal corresponding to the nystagmus...

Hereditary haemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is an autosomal dominant vascular disease. The clinical manifestations are epistaxis, mucocutaneous and gastrointestinal telangiectases, and arteriovenous malformations. There are two predominant types of HHT caused by mutations in Endoglin (ENG) and activin receptor-like kinase 1 (ALK1) (ACVRL1) genes, HHT1 and HHT2, ...