Purpose: Rhabdomyosarcoma (RMS) is a common pediatric soft-tissue tumor. In this study, we evaluated the efficacy and selectivity of drozitumab, a death receptor DR5-targeted therapeutic antibody, in RMS preclinical models. Experimental Design: A panel of 11 RMS cell lines was used for in vitro studies. The molecular marker predictive of response to drozitumab was interrogated. Selected RMS cel...

BACKGROUND Rheumatic heart disease (RHD) is a serious health concern in developing countries. Rheumatic mitral stenosis (RMS) is the most long-term sequel in RHD. The neutrophil to lymphocyte ratio (NLR) is a novel marker, and a higher NLR has been associated with poor clinical outcomes in various cardiovascular disorders. We evaluated the availability of NLR to predict severity of mitral steno...

Neurogenesis persists within a few restricted areas of the adult mammalian brain, giving rise to neurons that functionally integrate into preexisting circuits. One of these areas, the subventricular zone (SVZ), was believed, until recently, to be the unique source providing the adult olfactory bulb (OB) with newborn neurons. Because of the fact that neuroblasts derived in the SVZ migrate throug...

When employees care about the level of service provision or its quality, they may be motivated to perform tasks beyond their strict job description. But such care only motivates e¤ort if workers believe it will have an impact, i.e., when what they does ‘matters’ for output, and will not do so to enhance pro...ts. Since nonpro...t status means that management is not directly concerned with pro.....

User-generated content has been ubiquitous on the Internet. This paper studies the e ect of user-generated content on competing rms' product design decisions when they face uncertain consumer taste. User-generated content makes rms better informed about consumer taste because of the additional information revealed, and it also makes their information more correlated because user-generated conte...

Rhabdomyosarcoma (RMS), which represents the most frequent soft tissue sarcoma in pediatric populations, is classified into two major subtypes: embryonal RMS (ERMS) and alveolar RMS (ARMS). ARMS subtype, which shows greater aggressiveness and proneness to metastasis with respect to ERMS, are characterized, in about 75% of cases, by specific chromosomal translocations that involve PAX and FOXO1 ...

Multidrug resistance (MDR) is a common problem in the treatment of childhood rhabdomyosarcoma (RMS). A complete reversal of MDR is currently not possible. The aim of this study was to investigate the role of glutathione-S-transferase (GST) as mechanism of MDR in childhood RMS and to analyze possible reversal strategies. Female athymic mice underwent xenotransplantation with embryonal or alveola...

This paper reviews the development of a root mean squared error (RMS) flaw sizing criterion. The effect of using an RMS error criterion for the sizing performance of the PISC II [1-3] inspection teams is investigated. A crucial part of establishing an RMS error sizing criterion is the decomposition of the components in the RMS error into the sum of the squares of the mean error, the standard er...