نتایج جستجو برای: riz
تعداد نتایج: 349 فیلتر نتایج به سال:
FOG1 is a transcriptional regulator that acts in concert with the hematopoietic master regulator GATA1 to coordinate the differentiation of platelets and erythrocytes. Despite considerable effort, however, the mechanisms through which FOG1 regulates gene expression are only partially understood. Here we report the discovery of a previously unrecognized domain in FOG1: a PR (PRD-BF1 and RIZ) dom...
Adult stem cell quiescence is critical to ensure regeneration while minimizing tumorigenesis. Epigenetic regulation contributes to cell cycle control and differentiation, but few regulators of the chromatin state in quiescent cells are known. Here we report that the tumor suppressor PRDM2/RIZ, an H3K9 methyltransferase, is enriched in quiescent muscle stem cells in vivo and controls reversible ...
The PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1) is a transcription repressor with a pivotal role in plasma-cell differentiation. We identified clonal inactivating mutations in PRDM1 in the diffuse large B-cell lymphoma (DLBCL) cell line OCI-Ly3 and in 8 of 35 de novo clinical DLBCL samples. The mutational spectrum consists predominantly (7 cases) of single-nucleotide mutations affect...
The 2-m robotic Liverpool Telescope (LT) reacted promptly to the high-redshift (z = 4.048) gamma– ray burst GRB 060206. The afterglow was identified automatically and multicolor riz imaging program was triggered without human intervention. Combining our data with those obtained from later follow-ups provides a well-sampled optical light-curve from 5 minutes to >2d after the gamma event. The lig...
Environmentally-friendly management techniques such as arbuscular mycorrhizal fungi (AMF) strategies are urgently required to improve plant nutrition and overcome abiotic stress. In this study, we evaluated the influence of symbiotic AMF on four pistachio rootstocks subjected drought (100 % control, 80 %, 60 40 field capacity treatments) salinity (0.91 7.57, 16.12, 24.63 dS/m using NaCl stress ...
Prdm genes encode transcription factors with a subtype of SET domain known as the PRDF1-RIZ (PR) homology domain and a variable number of zinc finger motifs. These genes are involved in a wide variety of functions during animal development. As most Prdm genes have been studied in vertebrates, especially in mice, little is known about the evolution of this gene family. We searched for Prdm genes...
▼ Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10–20 % of patients with diabetes, or roughly 40–50 % patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include stre...
PURPOSE PR (PRDI-BF1 and RIZ) domain proteins (PRDM) are a subfamily of the kruppel-like zinc finger gene products that play key roles during cell differentiation and malignant transformation. The aim of the present study was to begin to examine the involvement of epigenetic alteration of PRDM expression in gastric and colorectal cancer. EXPERIMENTAL DESIGN We used real-time PCR to assess exp...
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