نتایج جستجو برای: ring alphabeta

تعداد نتایج: 123716  

Journal: :Journal of molecular biology 2001
J F Kameni Tcheudji L Lebeau N Virmaux C G Maftei R H Cote C Lugnier P Schultz

Phosphodiesterase 6 (PDE6), a multisubunit (alphabetagamma(2)delta) enzyme, plays a major role in visual function by hydrolysing cGMP in response to a light stimulus. Solubilized bovine rod PDE6 molecules depleted of their gamma subunits were purified to homogeneity from bovine retinal rods and their molecular organization was investigated by electron microscopy. Image analysis of single partic...

Journal: :The Journal of biological chemistry 2006
Claudia Bossen Karine Ingold Aubry Tardivel Jean-Luc Bodmer Olivier Gaide Sylvie Hertig Christine Ambrose Jürg Tschopp Pascal Schneider

Ligands of the tumor necrosis factor superfamily (TNFSF) (4-1BBL, APRIL, BAFF, CD27L, CD30L, CD40L, EDA1, EDA2, FasL, GITRL, LIGHT, lymphotoxin alpha, lymphotoxin alphabeta, OX40L, RANKL, TL1A, TNF, TWEAK, and TRAIL) bind members of the TNF receptor superfamily (TNFRSF). A comprehensive survey of ligand-receptor interactions was performed using a flow cytometry-based assay. All ligands engaged ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Ottavio V Vitolo Antonino Sant'Angelo Vincenzo Costanzo Fortunato Battaglia Ottavio Arancio Michael Shelanski

Changes in hippocampal function seem critical for cognitive impairment in Alzheimer's disease (AD). Although there is eventual loss of synapses in both AD and animal models of AD, deficits in spatial memory and inhibition of long-term potentiation (LTP) precede morphological alterations in the models, suggesting earlier biochemical changes in the disease. In the studies reported here we demonst...

In the combination of 5-fluorophenyl-1, 3, 7, 9-tetra methyl pyrido [2, 3, d, d, 5, 6 di pyrimidine -2, 4, 6, and 8 tetron, there are 4 rings, respectively, ring that is attached to the halogen ring A and, respectively, a ring The lower and the right to the left of the ring A are called C, B, and D. Calculations and studies show that the amount of aromatics in halogen-ring A in all cases has th...

For a ring endomorphism $alpha$ and an $alpha$-derivation $delta$, we introduce a concept, so called skew $pi$-Armendariz ring, that is a generalization of both $pi$-Armendariz rings, and $(alpha,delta)$-compatible skew Armendariz rings. We first observe the basic properties of skew $pi$-Armendariz rings, and extend the class of skew $pi$-Armendariz rings through various ring extensions. We nex...

Journal: :Journal of immunology 1998
S H Park J H Roark A Bendelac

Although there is evidence that some members of the CD1 gene family may present particular types of foreign Ags, such as mycobacterial lipid Ags or synthetic hydrophobic peptides, to alphabeta T cells, most CD1 isotypes share the unusual property of being recognized by a high frequency of naturally autoreactive alphabeta T cells. In the case of mouse CD1.1 and its human counterpart CD1d, a sign...

Journal: :Biochemistry and cell biology = Biochimie et biologie cellulaire 2001
W A Houry

The bacterial chaperonin GroEL functions with its cofactor GroES in assisting the folding of a wide range of proteins in an ATP-dependent manner. GroEL-GroES constitute one of the main chaperone systems in the Escherichia coli cytoplasm. The chaperonin facilitates protein folding by enclosing substrate proteins in a cage defined by the GroEL cylinder and the GroES cap where folding can take pla...

Journal: :The Biochemical journal 2000
J J Lacapère J C Robert A Thomas-Soumarmon

When gastric H(+),K(+)-ATPase-containing microsomes are solubilized by detergents, a rapid loss of ATPase activity is generally observed. In this article, SDS/PAGE of octa(ethylene glycol)dodecyl monoether (C(12)E(8))- and n-dodecyl beta-d-maltoside-solubilized microsomes and their purifications by affinity chromatography on Reactive Red column reveal that inactivation is due to two main effect...

Journal: :The Journal of Experimental Medicine 2005
Edda Fiebiger Domenico Tortorella Marie-Helene Jouvin Jean-Pierre Kinet Hidde L. Ploegh

The human high affinity receptor for IgE (FcepsilonRI) is a cell surface structure critical for the pathology of allergic reactions. Human FcepsilonRI is expressed as a tetramer (alphabetagamma(2)) on basophils or mast cells and as trimeric (alphagamma(2)) complex on antigen-presenting cells. Expression of the human alpha subunit can be down-regulated by a splice variant of FcepsilonRIbeta (bet...

Journal: :Journal of immunology 2009
Phi Truong Sara Heydari Lucile Garidou Dorian B McGavern

Persistence of even the stealthiest viruses can perturb immune function either to the benefit or detriment of the host. Lymphocytic choriomeningitis virus (LCMV) establishes lifelong, systemic persistence when introduced in utero or at birth. Despite a highly evolved host-pathogen relationship, LCMV cannot escape detection by the innate immune system, which results in chronic stimulation of the...

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